Biodegradable Stents in the Management of Stenoses of the Large Airways

Launched by LUDEK STEHLIK · Dec 2, 2015

Keywords

ClinConnect Summary

Background:

The ideal airway stent has yet to be developed. Biodegradable (BD) stents are made of knitted polymer fibers that degrade when placed in the body; extraction of the device is, therefore, unnecessary. Several in vitro and in vivo studies of tracheal BD stents composed of various materials have been conducted.

Polydioxanone is a biodegradable polymer in the polyester family, which has attracted a lot of interest due to its exquisite biocompatibility and is currently available on the market in the form of absorbable suture material. It is degraded by hydrolysis (of its ester bond...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • significant large airway stenoses
• • benign tracheobronchial stenosis of any origin in participants who can not go for surgery, or who refuse surgical treatment
• • benign tracheobronchial stenoses of any origin when the surgery is planed after some delay, benign tracheobronchial stenoses when the effect of anti- inflammatory or anti-infective treatment is expected
• • malignant tracheobronchial stenoses due to extrinsic compression when exhausted curative modalities
• • malignant stenoses from extrinsic compression in participants undergoing the actinotherapy or receiving systemic anticancer therapy
• Exclusion Criteria:
• • stenoses of any origin which can be treated primarily surgically
• • stenoses caused by intraluminal growth of tumor, tracheoesophageal or bronchoesophageal fistulas
• • pregnancy