Women Informed to Screen Depending on Measures of Risk (Wisdom Study)

Launched by UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · Dec 2, 2015

Keywords

ClinConnect Summary

The Wisdom Study is a clinical trial exploring a new approach to breast cancer screening. Traditionally, many doctors recommend that all women start having annual mammograms at age 40, regardless of their personal risk factors. While mammograms can help find cancers early, they also come with downsides, such as false alarms leading to unnecessary stress and procedures. This study aims to see if a more personalized screening schedule, based on each woman's individual risk of breast cancer, can improve outcomes and reduce anxiety. Participants will receive a risk assessment that considers their family history, breast density, and genetic factors. Women identified as having a higher risk will have more frequent screenings, while those at lower risk will have them less often, but never below recommended guidelines.

To be eligible for the study, women should be between 30 and 74 years old, and live in specific states or have coverage from a participating health plan. Importantly, the study is open to anyone who identifies as female. Participants can expect a supportive environment where they can choose their type of care, helping to ease concerns about being randomly assigned to a particular treatment. If successful, this study could change how breast cancer screening is approached in the United States, allowing women to better understand their risk and potentially avoiding unnecessary worry and procedures.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Female\*
• • 2. Age 30 years to 74 years old
• • 3. Reside in California, North Dakota, South Dakota, Iowa, Minnesota, Alabama, Louisiana, Illinois OR have coverage from a participating health plan\*\*.
• • NOTE\*: As of 2019, we are now enrolling all persons who identify as female, and will capture both their sex at birth and gender identity in the baseline survey.
• • NOTE\*\*: Depending on funding for study services, recruitment will expand nationwide, therefore criteria (c) will not apply if funding allows. As of 2019, recruitment is available nationwide.
• Exclusion Criteria:
• • 1. Prior Breast cancer or ductal carcinoma in situ (DCIS) diagnosis
• • 2. Prior prophylactic bilateral mastectomy
• • 3. Inability to provide consent
• • 4. Non-English or Spanish proficiency (Spanish participation available: June 2019)