Functional Magnetic Resonance Imaging Sleep Study With Auditory Stimuli

Launched by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (NINDS) · Dec 10, 2015

Keywords

ClinConnect Summary

This clinical trial is studying how our brains react to sounds while we sleep, using advanced imaging techniques called functional magnetic resonance imaging (fMRI) and electroencephalogram (EEG). The researchers want to understand how different sound levels can wake someone up from deep sleep, as deeper sleep means it takes louder sounds to wake a person. They will invite healthy individuals aged 18 to 34 who can comfortably sleep on their backs for several hours to participate.

Participants will first go through a screening process that includes health checks and a hearing test. If eligible, they'll follow a special two-week routine to prepare for their overnight visits, where they will sleep in a scanner that takes pictures of their brain while sounds are played to them. They'll wear small sensors to monitor their brain activity and movements. It's important to note that participants should not have certain health conditions or habits, like significant alcohol or caffeine use, that could affect the study. Overall, this trial aims to help us learn more about sleep and brain activity, which could improve our understanding of how sound affects our rest.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • 1. able to give informed consent;
• • 2. in good general heath;
• • 3. between the ages of 18 and 34 years;
• • 4. able to sleep on your back for several hours (with breaks).
• EXCLUSION CRITERIA:
• • 1. have a medical condition like diabetes or uncontrolled hypertension;
• • 2. have a psychiatric or neurologic condition like depression or stroke;
• • 3. have ever had a seizure;
• • 4. have a sleep disorder like insomnia or sleep apnea;
• • 5. work night shifts;
• • 6. have metal in your body such as pacemakers, metal prostheses, or aneurysm clips that would make MRI scanning unsafe;
• • 7. are pregnant or nursing;
• • 8. drink too much caffeine (6 or more cups of coffee per day or 10 or more cups of caffeinated soda per day);
• • 9. use too much alcohol (15 or more alcoholic beverages per week for men and 8 or more alcoholic beverages per week for women);
• • 10. use too much nicotine (nicotine use within 30 minutes of waking);
• • 11. are afraid of enclosed spaces;
• • 12. have known hearing problems;
• • 13. regularly use a prescription or over-the-counter drug to help you sleep or stay awake;
• • 14. are an employee, contractor, or volunteer of the Laboratory of Functional and Molecular Imaging in the National Institute of Neurological Disorders and Stroke.