Non Invasive Methods for Differential Diagnosis Radionecrosis/Recurrence After Radiosurgery of Brain Metastases

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Dec 17, 2015

Keywords

ClinConnect Summary

The purpose of the study is to assess a diagnostic strategy by monitoring brain metastases after radio surgical treatment . Data from two non-invasive techniques: PET-FET (positron emission tomography using 1-Fluoro-Ethyl-Tyrosine) and MSR (magnetic resonance spectroscopy) will be compared to histological examination (gold standard) in patients with active persistent and increased lesion 4 months after radiosurgery. The study should develop a decision-making algorithm based on non-invasive tests and allow improving the length and quality of life of these patients.

Early differential diagno...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • age between 18 and 75 years.
• • Patient treated with radiosurgery for one or more brain metastases Free -Intervally between radiosurgical treatment and inclusion in the study at least four months.
• • Lesion (S) treated (s) and followed (s) with the criteria for a clinically active lesion (progressive deficit, seizures, intracranial hypertension steroid-dependent) and / or MRI (increased volume of contrast enhancement with peri-lesional edema and mass effect on two successive examinations at 1 month interval).
• • Karnofsky index\> 50.
• • Prognostic compatible for survival with a follow-up at least three months from the date of inclusion.
• • Effective contraception for women of childbearing potential or negative pregnancy test within 72 hours.
• • Signed informed consent obtain
• • Affiliation to the social security system
• Exclusion Criteria:
• • Contraindication to MRI examination
• • Clearance of the creatinine incompatible with the injection of gadolinium
• • No potential follow-up in middle or long term
• • Pregnancy