Tumor Related Epilepsy

Launched by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE (NINDS) · Dec 23, 2015

Keywords

ClinConnect Summary

This clinical trial is studying how surgery can help people who have seizures caused by brain tumors, a condition known as tumor-related epilepsy. The goal is to see if removing the tumor can reduce or even eliminate these seizures, improving the quality of life for the participants. To be eligible for the trial, individuals must be at least 8 years old and have a brain tumor that has caused seizures. It's important that they are willing to undergo surgery as part of the treatment.

Participants in the trial can expect to undergo several tests, including medical exams and brain scans, to evaluate their condition before surgery. They will also keep a diary to track their seizures before and after the surgery. After the surgery, which involves removing both the tumor and the area of the brain where seizures start, participants will stay in the hospital for up to a week for recovery. Follow-up visits will be scheduled to monitor their progress. This study is currently recruiting participants of all genders and aims to help improve treatment options for those affected by this challenging condition.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• To be eligible for entry into the study, a candidate must meet all the following criteria:
• • Be 8 years of age or older.
• • Have solitary primary or recurrent brain tumor with associated seizures. Brain tumor may be diagnosed radiologically. Associated seizures are defined as those with activity starting within three months of radiologic diagnosis of the primary or recurrent tumor. In cases when the timing of seizure activity is unclear with respect to the timing of diagnosis, seizures will be considered associated with the tumor if seizure semiology is consistent with that location. Ongoing seizures are not required. Patients can be included if they have had a single previous seizure. Patients who have not experienced seizures after institution of anti-convulsant therapy are not excluded.
• EXCLUSION CRITERIA:
• Candidates will be excluded if they:
• • -At the time of enrollment, lack consent capacity due to cognitive impairment that would make them incapable of understanding the explanation of the procedures in this study. Cognitive capacity to consent will be determined at the time of enrollment. Patients with mental disorders or those patients who are cognitively impaired yet still retain consent capacity will not be excluded. Children may be enrolled if there is a parent or guardian able to consent on their behalf.