Stereotactic Radiosurgery (SRS) Dose-Escalation Study for Brain Metastasis

Launched by UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER · Dec 30, 2015

Keywords

ClinConnect Summary

This clinical trial is exploring a treatment called Stereotactic Radiosurgery (SRS) for patients with brain metastases, which are cancerous spots in the brain that have spread from other parts of the body. The goal of the study is to test whether giving a higher dose of radiation than what is currently standard can help control the cancer better, improve survival rates, and enhance patients' quality of life. The trial is open to adults aged 18 and older who have specific types of cancer and brain metastases that meet certain criteria.

To be eligible, participants must have a confirmed cancer diagnosis (excluding certain types like small cell lung cancer) and show evidence of brain metastases via imaging tests like MRI or CT scans. They should have ten or fewer brain metastases, with the largest one measuring no more than 3 centimeters. Participants will undergo the SRS procedure, which is a non-invasive treatment, and they will be monitored for how well it works and any side effects. It's important for potential participants to discuss their medical history with their doctors to ensure they meet the requirements and understand the study's implications.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• • 1. Biopsy-proven non-hematopoietic malignancy, except for small cell lung cancer, germ cell cancer, or unknown primary tumor.
• • 2. Radiographic evidence by MRI (or by CT scan with CT contrast if ineligible or intolerant of MRI) of brain metastasis. (If patient is unable to tolerate MRI contrast, an MRI without contrast is acceptable if lesions are visible)
• • 3. All brain metastases must be outside the brain stem (midbrain, pons and medulla).
• • 4. Patient must have 10 or less brain metastases.
• • 5. The maximum diameter of any lesion must be less than or equal to 3.0 cm.
• 6. Previous treatment with surgery, radiation, chemotherapy, immunotherapy or any targeted agents are allowed provided that:
• • Radiation was not to the brain.
• • Surgery to the brain was \> 7 days prior to SRS and there remains at least one additional brain metastasis that can be targeted with SRS
• • 7. Age ≥ 18 years.
• • 8. ECOG Performance Score of 2 or better/Karnofsky Performance Status score of 50-60 or better.
• • 9. All men, as well as women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.
• A female of child-bearing potential is any woman (regardless of sexual orientation, marital status, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria:
• • Has not undergone a hysterectomy or bilateral oophorectomy; or
• • Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months).
• • 10. Ability to understand and the willingness to sign a written informed consent.
• • Exclusion Criteria
• • 1. Patients had craniotomy and surgery to the brain within 7 days from the date of SRS.
• • 2. Patients with leptomeningeal metastasis.
• • NOTE: For the purposes of exclusion, LMD is a clinical diagnosis, defined as positive CSF cytology and/or equivocal radiologic or clinical evidence of leptomeningeal involvement. Patients with leptomeningeal symptoms in the setting of leptomeningeal enhancement by imaging (MRI) would be considered to have LMD even in the absence of positive CSF cytology, unless a parenchymal lesion can adequately explain the neurologic symptoms and/or signs. In contrast, an asymptomatic or minimally symptomatic patient with mild or nonspecific leptomeningeal enhancement (MRI) would not be considered to have LMD. In that patient, CSF sampling is not required to formally exclude LMD, but can be performed at the investigator's discretion based on level of clinical suspicion.
• • 3. Patients with a contraindication to both MRI (with or without contrast) and CT scan (with contrast)
• • 4. Patients with life expectancy \< 3 months.
• • 5. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that, in the opinion of the investigator, would limit compliance with study requirements.
• • 6. Subjects must not be pregnant or nursing at the time of SRS treatment due to the potential for congenital abnormalities and the potential of this regimen to harm nursing infants.