Nuts and Olestra for Persistent Organic Pollutant Reduction (NO-POPs) Trial

Launched by UNIVERSITY OF CALIFORNIA, SAN DIEGO · Feb 2, 2016

Keywords

ClinConnect Summary

Persistent organic pollutants (POPs) are mostly fat-soluble halogenated chemicals with very long half-lives. POPs are endocrine disruptors, and have been associated with increased risk for diabetes, alterations in thyroid function, hypertension, dyslipidemia and neurobehavioral alterations in studies of children, and adults including the elderly. Some of the most prevalent POPs include organochlorine pesticides, polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs).

Most POPs are excreted in bile due to their lipophilic nature. However, a substantial amount is reabsor...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Reside in the San Diego area
• • BMI ≥18.0 kg/m2 and ≤30 kg/m2
• • Non-smoker
• • Willing and able to participate in clinic visits, bi-monthly supply pick-up, telephone and Internet communications at specified intervals
• • Able to provide data through questionnaires and by telephone
• • Willing to maintain contact with the investigators for 6 months
• • Willing to allow blood collections
• • Willing to provide stool samples
• • No known allergy to tree nuts
• • No digestive issues with olestra, chips, or nuts
• Exclusion Criteria:
• • Nut allergies
• • Smoker
• • Diabetes, kidney disease or liver disease
• • Concurrent acute or chronic gastro-intestinal conditions (e.g. inflammatory bowel disease, irritable bowel syndrome, concurrent diarrhea from any cause)
• • Familial hypercholesterolemia
• • Clotting problems or use of Coumadin,
• • Inability to participate in physical activity because of severe disability
• • History or presence of a co-morbid diseases for which diet modification may be contraindicated
• • Self-reported pregnancy or breastfeeding or planning a pregnancy within the next year
• • Currently actively involved in another diet intervention study or a weight loss program
• • A history or presence of a significant psychiatric disorder or any other condition that, in the investigator's judgement, would interfere with participation in the trial