The Effect of Probiotic Streptococci and pH-rising Components on the Oral Microbial Flora
Launched by GÖTEBORG UNIVERSITY · Feb 4, 2016
Trial Information
Current as of August 11, 2025
Completed
Keywords
ClinConnect Summary
The aim was to analyse the effect of daily intake of probiotic alpha-haemolytic facultative anaerobic streptococci (Streptococcus oralis), pH-rising components and Stevia on the oral microflora in hyposalivated subjects.
Material and methods: Subjects with hyposalivation (unstimulated secretion rate of \< 0.1 ml/min and/or a stimulated secretion rate \< 0.7 ml/min) and ≥ 10 000 cfu/ml of mutans streptococci and/or lactobacilli on the tongue or in the supragingival plaque were included. Eighteen subjects used probiotic tablets (≥ 4/day) and gel (once a week) for 3 months and 9 used placebo ...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • No open wounds in the oral cavity
- • ≥ 10 own teeth
- • Experienced dry mouth for at least 1 year
- • An unstimulated salivary secretion rate \< 0.1 ml/min
- • A stimulated secretion rate \< 0.7 ml/min and high numbers (≥ 10000 cfu/ml) of lactobacilli and/or mutans streptococci on the tongue and/or in dental plaque
- Exclusion Criteria:
- • Removable prosthesis
- • Reduced immune defence
- • Serious heart diseases
- • Implanted joints or heart valves
- • Lactose intolerance (the probiotic streptococci are freeze-dried in skim milk)
About Göteborg University
Göteborg University, a leading academic institution in Sweden, is committed to advancing healthcare through innovative research and clinical trials. With a strong focus on interdisciplinary collaboration, the university leverages its extensive expertise in various fields, including medicine, pharmacology, and social sciences, to address pressing health challenges. By sponsoring clinical trials, Göteborg University aims to contribute to the development of new therapies and improve patient outcomes, while adhering to the highest ethical standards and regulatory requirements. Their dedication to rigorous scientific inquiry and community engagement positions them as a pivotal player in the global health research landscape.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Gothenburg, , Sweden
Patients applied
Trial Officials
Annica Almstahl, Assoc. prof.
Principal Investigator
Goteborg University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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