Dose Response of Epinephrine

Launched by UNIVERSITY OF MARYLAND, BALTIMORE · Feb 22, 2016

Keywords

ClinConnect Summary

This clinical trial is studying the effects of epinephrine, a hormone that helps the body respond to low blood sugar, on healthy individuals. Researchers want to understand how different doses of epinephrine can influence blood vessel function and the body’s ability to prevent blood clots. This information is important because it may help improve our understanding of diabetes complications and how the body manages them.

To participate in this study, you need to be a healthy adult aged 18 to 55 with a body mass index (BMI) over 21. Unfortunately, if you are pregnant, breastfeeding, or have certain health conditions like severe high blood pressure or heart disease, you won’t be eligible to join. If you qualify, you can expect to undergo some tests and receive different doses of epinephrine while being closely monitored. This study is currently looking for participants, and your involvement could contribute to valuable research in diabetes care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • healthy controls age 18-55 yr.
• • Body mass index \>21 kg · m-2
• Exclusion Criteria:
• • Pregnant or breastfeeding women
• • Subjects unwilling or unable to comply with approved contraception measures
• • Subjects unable to give voluntary informed consent
• • Subjects on anticoagulant drugs, anemic or with known bleeding diatheses
• • Subjects with a history of severe, uncontrolled hypertension, heart disease, cerebrovascular incidents
• • Current tobacco use
• • Subjects with any known allergies to any of the study medications being used
• • Physical Exam Exclusion Criteria
• • Uncontrolled severe hypertension (i.e., blood pressure greater than 160/100)
• • Clinically significant cardiac abnormalities (e.g. heart failure, arrhythmia)
• • Pneumonia treatment or hospitalization within 2 weeks prior to enrollment (study visit)
• • Hepatic failure / jaundice
• • Renal failure
• • Cerebrovascular accident occurrence or hospitalization within 4 weeks prior to enrollment
• • Fever greater than 38.0 degrees C
• • Screening Laboratory Tests Exclusion Criteria
• • Hematocrit lower than 32 %
• • White blood cell (WBC) count lower than 3 thou/ul or greater than 14 thou/ul
• • Liver function tests: serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic-pyruvic transaminase (SGPT) greater than twice upper limit of normal range
• • Alkaline phosphatase greater than 150U/L
• • Total bilirubin (TBil) greater than 2 mg/dl
• • Estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m2
• • Positive human immunodeficiency virus (HIV), Hepatitis B or Hepatitis C
• • Any abnormal cardiac response during multi-stage exercise test (if over 40 years of age)