Molecular, Cellular, and Genetic Characterization of Human Adipose Tissue and Its Role in Metabolism

Launched by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES (NIDDK) · Feb 25, 2016

Keywords

ClinConnect Summary

This clinical trial is focused on understanding how fat and muscle in our bodies help manage energy and metabolism, which is important for overall health. Researchers are particularly interested in a type of fat called brown adipose tissue (BAT), which plays a role in burning calories. By studying fat and muscle tissues during planned surgeries at the National Institutes of Health (NIH), the goal is to gather information that could lead to new treatments for obesity and related health issues.

To participate in this study, you need to be at least 18 years old and scheduled for surgery at the NIH where tissue samples can be collected. This study won't require any extra visits or procedures; the tissue will be collected during your surgery, and any muscle tissue taken will come from areas that would otherwise be discarded. After your surgery, some blood samples will also be collected. All participants will receive detailed information about the study, including any risks, before agreeing to take part. Your help in this research could make a significant difference in understanding energy use in the body!

Gender

ALL

Eligibility criteria

• • IINCLUSION/EXCLUSION CRITERIA FOR SUBJECTS UNDERGOING SURGERY (COHORT 1)
• • Male or female
• • Any ethnicity
• • 18 years or older
• • Subject undergoing planned, clinically-indicated surgical procedure at the NIH Clinical Center in which tissue will be accessible and available for collection by the Operating Surgeon.
• EXCLUSION CRITERIA:
• • -None
• INCLUSION/EXCLUSION CRITERIA FOR ALL OTHER SUBJECTS (HEALTHY VOLUNTEERS AND NON-SURGICAL PATIENTS (COHORT 2):
• • Male or female
• • Any ethnicity
• • 18-80 year
• • For supraclavicular or dorsocervical adipose biopsy: 18F-FDG PET/CT Scan images available in the CRC PACS system (performed as part of separate protocol)
• EXCLUSION CRITERIA:
• • History of keloids.
• • Currently taking blood thinning or anti-inflammatory medications including anti-platelet or antithrombotic medications.
• • Pregnancy
• • History of pacemaker, metallic heart valves, aneurysm clip, pedicle screws, metallic foreign body in eye, or other metallic implant only if using fusion technology for the biopsy procedure.
• • Psychological conditions including (but not limited to) clinical depression, bipolar disorders, or forms of mental incapacity that would be incompatible with safe and successful participation in this study.
• • Addiction to alcohol or substances of abuse within the last 5 years; current use of drugs or alcohol (CAGE greater than or equal to 2).
• • All subjects will be fully informed of the aims, nature, and risks of the study prior to giving written informed consent.