Vaginal Progesterone in Twin With Short Cervix

Launched by AIN SHAMS UNIVERSITY · Feb 27, 2016

Keywords

ClinConnect Summary

Aim of the work The aim of this study is to assess the efficacy of the use of vaginal progesterone as a method of prevention of preterm labour in twin gestations with short cervix .

Study Design:

The study is designed as randomized ,placebo-controlled, clinical trial . All women with dichorionic diamniotic twin pregnancy will be followed up in the antenatal care at the out patient clinic. Randomization of cases will be done by computer method . 156 women with dichorionic diamniotic twin pregnancy and cervical length 10mm to 25mm detected on transvaginal sonogram between 20w to 24w gestati...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• * ( All pregnant women known to have Dichorionic Diamniotic twins diagnosed on 12 week dating scan will be offered transvaginal ultrasound scan to assess cervical length at 20-24 week anomaly scan ) and so inclusion criteria include:
• • 1. ( Dichorionic Diamniotic twins ) and both twins are living .
• • 2. (Short Cervix 10-25mm) Diagnosed by transvaginal ultrasound scan between 20-24 weeks .
• Exclusion Criteria:
• • 1 - Cervical cerclage in place or planned . 2- on tocolytic drugs . 3- medically indicated preterm delivery \< 35w of gestation . 4- known allergy to progesterone or peanuts ( as the active treatment contain peanut oil) .
• • 5- known contraindication to progesterone
• • 1. Liver dysfunction or disease
• • 2. Known or suspected malignancy of breast or genital organs
• • 3. Active thromboembolic disorder , or history of hormone-associated thromboembolic disorder 6- known major structural or chromosomal fetal abnormality . 7- Rupture of fetal membranes (leakage of amniotic fluid one or both sacs)