The Effect of REcombinant Human Thrombopoietin (rhTPO) on Sepsis Patients With aCUte Severe thrombocytopEnia

Launched by RUILAN WANG · Mar 11, 2016

Keywords

ClinConnect Summary

This clinical trial is investigating whether a treatment called recombinant human thrombopoietin (rhTPO) can help patients with sepsis who also have very low platelet levels, a condition known as thrombocytopenia. The study aims to see if rhTPO can quickly increase platelet counts, help patients recover faster, reduce the need for blood transfusions, and ultimately lower the risk of dying within 28 days. This is important because sepsis can cause serious complications, and low platelet counts can make recovery even harder.

To participate in this trial, patients must be between 65 and 74 years old with a confirmed infection and a specific level of organ dysfunction. They should also have very low platelet counts (less than 50,000 per microliter of blood). However, individuals with certain medical histories, such as recent chemotherapy or serious organ issues, are not eligible. Those who join the trial can expect close monitoring and support from the medical team while they receive rhTPO treatment, and their progress will be tracked throughout the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Confirmed or clinical diagnosed infection
• • 2. The change of Sequential Organ Failure Assessment(ΔSOFA) score ≥ 2
• • 3. PLT\< 50×10\^9/L
• • 4. Informed consent
• Exclusion Criteria:
• • 1. History of the treatments with chemotherapeutic drugs or heparin within six months
• • 2. History of bone marrow stem cell disorders, malignancy, or immunologic diseases
• • 3. History of bone marrow, lung, liver, kidney, pancreas, or small bowel transplantation.
• • 4. Confirmed End-stage renal failure(GFR \<10ml/min，Scr\>707μmol/L)
• • 5. Confirmed Disseminated Intravascular Coagulation(DIC)
• • 6. Confirmed Hemorrhagic brain injury or need craniocerebral operation
• • 7. Died anticipated within 24 hours
• • 8. Known pregnancy or at breastfeeding