The Effect of HMB Supplementation on Adipose Tissue Inflammation and Metabolism

Launched by METABOLIC TECHNOLOGIES INC. · Mar 17, 2016

Keywords

ClinConnect Summary

Forty obese men (BMI 35-40 kg/m2,18-40 years of age) will be randomly assigned to one of four treatment interventions: 1) Calorie restricted; 2) Calorie restricted and HMB supplemented; 3) No calorie restriction; and 4) No calorie restriction and HMB-supplemented. Over the 8 week interventional period the calorie restricted group is expected to lose 3-5% of initial body weight. Anthropometric measures will be taken weekly, and dual energy x-ray absorptiometry (DXA) body composition and strength will be measured before and after 8-weeks of intervention. Blood and urine will be collected and ...

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Male
• • Non-smoker
• • Body mass index of 35-40 kg/m2
• • Age 18-40 years
• • Weight stable for past 6 months (\<5 lb. change)
• • In good health, free of chronic diseases/conditions that may impact measured outcomes
• • Willing and able to consume a weight loss diet
• • Willing and able to consume a daily nutritional supplement (in pill form)
• • Available for scheduled study commitments during the 2 months of study
• Exclusion Criteria:
• • Smoke
• • Take any cholesterol lowering or weight loss drugs or an drugs or supplements that affect blood lipids, insulin or body composition
• • Weigh greater 300 pounds due to weight, size and depth limitations of equipment
• • Take dietary supplements
• * Have a chronic disease such as:
• • Cardiopulmonary disease (e.g. recent myocardial infarction, unstable angina, stroke) or unstable disease
• • Severe orthopedic/musculoskeletal or neuromuscular impairments that would contradict exercise
• • Sensory impairments that interfere with following directions
• • Diagnosis if dementia
• • History of malignancy during the past 5 years
• • Diabetes mellitus