Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia
Launched by UMC UTRECHT · Apr 6, 2016
Trial Information
Current as of May 08, 2025
Recruiting
Keywords
ClinConnect Summary
The REMAP-CAP trial is a research study designed to find out which treatments work best for patients with community-acquired pneumonia, especially those who are very sick and need to be in the intensive care unit (ICU). The study is also set up to quickly test different treatments during respiratory pandemics, like COVID-19. Patients who are eligible for this trial are adults who have been admitted to the ICU within 48 hours of showing severe symptoms of pneumonia and may require breathing support or medications to help their heart function.
If someone participates in this trial, they can expect to receive one of several treatment options being studied to see which one helps them recover better. The trial is currently recruiting patients aged 18 and older, and it’s important to note that certain patients, such as those who have been in a healthcare facility recently or whose death is expected within the next day, are not eligible to join. For more details about participation and eligibility, interested individuals can visit the study's website.
Gender
ALL
Eligibility criteria
- REMAP-CAP PLATFORM INCLUSION CRITERIA:
- 1. Adult patient admitted to an ICU for severe CAP within 48 hours of hospital admission with:
- • 1. symptoms or signs or both that are consistent with lower respiratory tract infection AND
- • 2. Radiological evidence of new onset consolidation (in patients with pre-existing radiological changes, evidence of new infiltrate)
- 2. Up to 48 hours after ICU admission, receiving organ support with one or more of:
- • 1. Non-invasive or Invasive ventilatory support;
- • 2. Receiving infusion of vasopressor or inotropes or both
- PLATFORM EXCLUSION CRITERIA:
- 1. Healthcare-associated pneumonia:
- • 1. Prior to this illness, is known to have been an inpatient in any healthcare facility within the last 30 days
- • 2. Resident of a nursing home or long term care facility
- • 2. Death is deemed to be imminent and inevitable during the next 24 hours AND one or more of the patient, substitute decision maker or attending physician are not committed to full active treatment
- • 3. Previous participation in this REMAP within the last 90 days
- • REMAP-COVID PLATFORM INCLUSION CRITERIA
- • 1. Adult patients (≥ 18 years) admitted to hospital with acute illness due to suspected or proven pandemic infection.
- • REMAP-COVID PLATFORM EXCLUSION CRITERIA
- • 1. Death is deemed to be imminent and inevitable during the next 24 hours AND one or more of the patient, substitute decision maker or attending physician are not committed to full active treatment
- • 2. Patient is expected to be discharged from hospital today or tomorrow
- • 3. More than 14 days have elapsed while admitted to hospital with symptoms of an acute illness due to suspected or proven pandemic infection.
- • 4. Previous participation in this REMAP within the last 90 days
- DOMAIN-SPECIFIC ELIGIBLE CRITERIA:
- • Each domain may have additional eligibility criteria. Refer to the study website for more information (www.remapcap.org).
About Umc Utrecht
UMC Utrecht is a leading academic medical center in the Netherlands, renowned for its commitment to innovative research and high-quality patient care. As a prominent sponsor of clinical trials, UMC Utrecht leverages its extensive expertise in translational medicine and collaboration with various stakeholders to advance medical knowledge and improve therapeutic outcomes. The institution emphasizes ethical conduct and rigorous scientific standards, ensuring that all research activities contribute meaningfully to the global healthcare landscape. Through its robust clinical trial infrastructure, UMC Utrecht plays a vital role in facilitating the development of new treatments and enhancing patient wellbeing.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Ann Arbor, Michigan, United States
Toronto, Ontario, Canada
Brighton, England, United Kingdom
Winchester, England, United Kingdom
Adelaide, South Australia, Australia
Aberdeen, Scotland, United Kingdom
Westmead, New South Wales, Australia
Leicester, England, United Kingdom
New York, New York, United States
Harrow, England, United Kingdom
Liverpool, New South Wales, Australia
Brisbane, Queensland, Australia
Preston, England, United Kingdom
London, England, United Kingdom
Groningen, , Netherlands
Toronto, Ontario, Canada
London, England, United Kingdom
Perth, Western Australia, Australia
Bristol, England, United Kingdom
Chester, England, United Kingdom
London, England, United Kingdom
Maidstone, England, United Kingdom
Wolverhampton, England, United Kingdom
Utrecht, , Netherlands
Manchester, England, United Kingdom
Box Hill, Victoria, Australia
Bournemouth, England, United Kingdom
Dudley, England, United Kingdom
Gateshead, England, United Kingdom
Salisbury, England, United Kingdom
Chesterfield, England, United Kingdom
Portland, Oregon, United States
Reading, England, United Kingdom
Swindon, England, United Kingdom
Norwich, England, United Kingdom
London, England, United Kingdom
Toronto, Ontario, Canada
Jacksonville, Florida, United States
Brugge, , Belgium
Worcester, England, United Kingdom
Torquay, England, United Kingdom
Ipswich, England, United Kingdom
Christchurch, , New Zealand
Oxford, England, United Kingdom
London, , United Kingdom
South Shields, England, United Kingdom
Sunderland, England, United Kingdom
Lincoln, England, United Kingdom
Leicester, England, United Kingdom
Sheffield, England, United Kingdom
London, England, United Kingdom
Toronto, Ontario, Canada
Crewe, , United Kingdom
Concord, New South Wales, Australia
Toronto, Ontario, Canada
Liverpool, England, United Kingdom
Toowoomba, Queensland, Australia
Hannover, , Germany
Melbourne, Victoria, Australia
Bedford Park, South Australia, Australia
Ringwood East, Victoria, Australia
Footscray, Victoria, Australia
Limoges, , France
Melbourne, Victoria, Australia
Dublin, , Ireland
Dublin, , Ireland
Northampton, England, United Kingdom
Cardiff, Wales, United Kingdom
Wrexham, Wales, United Kingdom
Kingston, Ontario, Canada
Stockton On Tees, England, United Kingdom
Plymouth, , United Kingdom
Durham, England, United Kingdom
Whitehaven, England, United Kingdom
Nuneaton, England, United Kingdom
Taunton, England, United Kingdom
Leiden, , Netherlands
Kogarah, New South Wales, Australia
Glasgow, Scotland, United Kingdom
Guildford, , United Kingdom
Clayton, Victoria, Australia
New Orleans, Louisiana, United States
Sydney, New South Wales, Australia
Barcelona, , Spain
Ottawa, Ontario, Canada
Southampton, , United Kingdom
Gillingham, England, United Kingdom
Truro, England, United Kingdom
Den Bosch, , Netherlands
Nijmegen, , Netherlands
München, , Germany
Perth, Western Australia, Australia
Bankstown, New South Wales, Australia
Dubbo, New South Wales, Australia
Sydney, New South Wales, Australia
Hamilton, Ontario, Canada
London, , United Kingdom
Gent, , Belgium
Osaka, , Japan
Leeds, , United Kingdom
Leipzig, , Germany
Amersfoort, , Netherlands
Arnhem, , Netherlands
Zürich, , Switzerland
Canberra, Australian Capital Territory, Australia
Paris, , France
Blacktown, New South Wales, Australia
Sydney, New South Wales, Australia
Campbelltown, New South Wales, Australia
Ballarat, Victoria, Australia
Münster, , Germany
London, England, United Kingdom
Hereford, England, United Kingdom
Liverpool, England, United Kingdom
Stockport, England, United Kingdom
Wigan, England, United Kingdom
Augusta, Georgia, United States
Brantford, Ontario, Canada
Belfast, Northern Ireland, United Kingdom
Würzburg, , Germany
Santander, , Spain
Galway, , Ireland
Leipzig, , Germany
Prescot, England, United Kingdom
Yokohama, Kanagawa, Japan
Rotterdam, , Netherlands
Palermo, , Italy
Hamilton, , New Zealand
Gloucester, , United Kingdom
Brisbane, Queensland, Australia
Wirral, England, United Kingdom
London, England, United Kingdom
Tampere, , Finland
Surrey, British Columbia, Canada
Manchester, England, United Kingdom
Dartford, England, United Kingdom
Redcliffe, Queensland, Australia
Rotherham, England, United Kingdom
Nijmegen, , Netherlands
Dortmund, , Germany
London, England, United Kingdom
Wakayama, , Japan
Townsville, Queensland, Australia
Paris, , France
Jena, , Germany
Helsinki, , Finland
Berwick, Victoria, Australia
Berlin, , Germany
Brescia, , Italy
Adelaide, South Australia, Australia
London, , United Kingdom
Edinburgh, Scotland, United Kingdom
Tartu, , Estonia
Columbus, Ohio, United States
Berlin, , Germany
Zagreb, , Croatia
Leeds, England, United Kingdom
Newcastle, New South Wales, Australia
Southport, Queensland, Australia
Bury, , United Kingdom
Winnipeg, Manitoba, Canada
Córdoba, , Spain
London, England, United Kingdom
Caringbah, New South Wales, Australia
Berlin, , Germany
Swansea, Wales, United Kingdom
Maribor, , Slovenia
Winnipeg, Manitoba, Canada
Melbourne, Victoria, Australia
Winnipeg, Manitoba, Canada
Dorchester, , United Kingdom
Antrim, Northern Ireland, United Kingdom
Golnik, , Slovenia
Edmonton, Alberta, Canada
Middlesbrough, England, United Kingdom
Bendigo, Victoria, Australia
Newport, Wales, United Kingdom
Portsmouth, England, United Kingdom
Haifa, , Israel
Frimley, , United Kingdom
Valencia, , Spain
Providence, Rhode Island, United States
Sheffield, England, United Kingdom
Madrid, , Spain
Rockhampton, Queensland, Australia
Dax, , France
Warwick, , United Kingdom
Leeuwarden, , Netherlands
Dandenong, Victoria, Australia
Rotorua, , New Zealand
Riyadh, , Saudi Arabia
Coventry, England, United Kingdom
Leeds, England, United Kingdom
Birtinya, Queensland, Australia
Milan, , Italy
Utrecht, , Netherlands
Yokohama, Kanagawa, Japan
Paisley, Scotland, United Kingdom
Argenteuil, , France
New Plymouth, , New Zealand
Tübingen, , Germany
Sydney, New South Wales, Australia
Bridgend, Wales, United Kingdom
Belfast, , United Kingdom
Tauranga, , New Zealand
Adelaide, South Australia, Australia
West Bromwich, , United Kingdom
Auckland, , New Zealand
Cologne, , Germany
Brisbane, Queensland, Australia
Wagga Wagga, New South Wales, Australia
Montréal, Quebec, Canada
Rimini, , Italy
Subiaco, Western Australia, Australia
Belfast, Northern Ireland, United Kingdom
Geelong, Victoria, Australia
Perth, Western Australia, Australia
Wellington, , New Zealand
Cork, , Ireland
Orange, New South Wales, Australia
Brampton, Ontario, Canada
Dundee, Angus, United Kingdom
Frankfurt, , Germany
Chicago, Illinois, United States
Winston Salem, North Carolina, United States
Pittsburgh, Pennsylvania, United States
Frenchs Forest, New South Wales, Australia
Kingswood, New South Wales, Australia
Sydney, New South Wales, Australia
Darwin, Northern Territory, Australia
Caboolture, Queensland, Australia
Coopers Plains, Queensland, Australia
Logan, Queensland, Australia
Launceston, Tasmania, Australia
Ferntree Gully, Victoria, Australia
Sunshine, Victoria, Australia
Werribee, Victoria, Australia
Midland, Western Australia, Australia
Murdoch, Western Australia, Australia
Charleroi, , Belgium
Edegem, , Belgium
Calgary, Alberta, Canada
Calgary, Alberta, Canada
Calgary, Alberta, Canada
Calgary, Alberta, Canada
Edmonton, Alberta, Canada
Fredericton, New Brunswick, Canada
Fredericton, New Brunswick, Canada
Fredericton, New Brunswick, Canada
Hamilton, Ontario, Canada
Hamilton, Ontario, Canada
Kitchener, Ontario, Canada
Kitchener, Ontario, Canada
Saint Catharines, Ontario, Canada
Thunder Bay, Ontario, Canada
Toronto, Ontario, Canada
Lévis, Quebec, Canada
Montréal, Quebec, Canada
Montréal, Quebec, Canada
Montréal, Quebec, Canada
Montréal, Quebec, Canada
Québec, Quebec, Canada
Québec, Quebec, Canada
Sherbrooke, Quebec, Canada
Saskatoon, Saskatchewan, Canada
Chía, Cundinamarca, Colombia
Požega, , Croatia
Zagreb, , Croatia
Berlin, , Germany
Berlin, , Germany
Hamburg, , Germany
Nyíregyháza, , Hungary
Veszprém, , Hungary
ózd, , Hungary
Chennai, Tamil Nadu, India
Chennai, Tamil Nadu, India
Chennai, Tamil Nadu, India
Chennai, Tamil Nadu, India
Kawasaki, Kanagawa, Japan
Minami, Kumamoto, Japan
Tokyo, , Japan
Tokyo, , Japan
Tokyo, , Japan
Tokyo, , Japan
Bharatpur, , Nepal
Kathmandu, , Nepal
Kathmandu, , Nepal
Kathmandu, , Nepal
Groningen, , Netherlands
Auckland, , New Zealand
Auckland, , New Zealand
Auckland, , New Zealand
Whangarei, , New Zealand
Karachi, Sindh, Pakistan
Karachi, Sindh, Pakistan
Karachi, Sindh, Pakistan
Karachi, Sindh, Pakistan
Karachi, Sindh, Pakistan
Abrantes, , Portugal
Lisboa, , Portugal
Bucharest, , Romania
Barcelona, , Spain
Basildon, England, United Kingdom
Basingstoke, England, United Kingdom
Bath, England, United Kingdom
Birmingham, England, United Kingdom
Birmingham, England, United Kingdom
Blackburn, England, United Kingdom
Boston, England, United Kingdom
Bristol, England, United Kingdom
Burton On Trent, England, United Kingdom
Cambridge, England, United Kingdom
Cambridge, England, United Kingdom
Carlisle, England, United Kingdom
Chertsey, England, United Kingdom
Colchester, England, United Kingdom
Crumpsall, England, United Kingdom
Darlington, England, United Kingdom
Exeter, England, United Kingdom
Great Yarmouth, England, United Kingdom
High Barnet, England, United Kingdom
Huddersfield, England, United Kingdom
Ilford, England, United Kingdom
Kettering, England, United Kingdom
Liverpool, England, United Kingdom
Liverpool, England, United Kingdom
Liverpool, England, United Kingdom
London, England, United Kingdom
London, England, United Kingdom
London, England, United Kingdom
London, England, United Kingdom
London, England, United Kingdom
London, England, United Kingdom
London, England, United Kingdom
London, England, United Kingdom
Luton, England, United Kingdom
Maidstone, England, United Kingdom
Manchester, England, United Kingdom
Margate, England, United Kingdom
Milton Keynes, England, United Kingdom
Newcastle, England, United Kingdom
Newcastle, England, United Kingdom
Nottingham, England, United Kingdom
Nottingham, England, United Kingdom
Oldham, England, United Kingdom
Orpington, England, United Kingdom
Poole, England, United Kingdom
Portsmouth, England, United Kingdom
Redditch, England, United Kingdom
Romford, England, United Kingdom
Salford, England, United Kingdom
Slough, England, United Kingdom
Stoke On Trent, England, United Kingdom
Sunderland, England, United Kingdom
Sutton In Ashfield, England, United Kingdom
Swindon, England, United Kingdom
Torquay, England, United Kingdom
Tunbridge Wells, England, United Kingdom
Uxbridge, England, United Kingdom
Watford, England, United Kingdom
Westcliff On Sea, England, United Kingdom
Winchester, England, United Kingdom
Wirral, England, United Kingdom
York, England, United Kingdom
Belfast, Northern Ireland, United Kingdom
Belfast, Northern Ireland, United Kingdom
Derry, Northern Ireland, United Kingdom
Glasgow, Scotland, United Kingdom
Paisley, Scotland, United Kingdom
Abergavenny, Wales, United Kingdom
Bodelwyddan, Wales, United Kingdom
Carmarthen, Wales, United Kingdom
Cwmbran, Wales, United Kingdom
Pontyclun, Wales, United Kingdom
Morlaix, , France
Málaga, , Spain
Köln, , Germany
Amsterdam, , Netherlands
Dijon, , France
Córdoba, , Spain
Deventer, , Netherlands
Dieppe, , France
La Roche Sur Yon, , France
Waterford, , Ireland
Valencia, , Spain
Melun, , France
Bodelwyddan, Wales, United Kingdom
Ede, , Netherlands
Aurillac, , France
Cadiz, , Spain
Orléans, , France
London, England, United Kingdom
Milan, , Italy
Den Haag, , Netherlands
Palermo, , Italy
Bristol, , United Kingdom
Tours, , France
London, England, United Kingdom
Namur, , Belgium
Prague, , Czechia
Teplice, , Czechia
Beauvais, , France
Belfort, , France
Boulogne Billancourt, , France
Béthune, , France
Eaubonne, , France
Garches, , France
Le Mans, , France
Mont De Marsan, , France
Strasbourg, , France
Strasbourg, , France
étampes, , France
Cottbus, , Germany
Essen, , Germany
Petah Tikva, , Israel
Poriyya, , Israel
Milan, , Italy
Reggio Emilia, , Italy
Almelo, , Netherlands
Eindhoven, , Netherlands
Roermond, , Netherlands
Uden, , Netherlands
Lisboa, , Portugal
Belgrade, , Serbia
Belgrad, , Serbia
Niš, , Serbia
Ourense, , Spain
Tortosa, , Spain
Blackburn, England, United Kingdom
Boston, England, United Kingdom
Bristol, England, United Kingdom
Carlisle, England, United Kingdom
Chertsey, England, United Kingdom
Gateshead, England, United Kingdom
Great Yarmouth, England, United Kingdom
Huddersfield, England, United Kingdom
London, England, United Kingdom
London, England, United Kingdom
London, England, United Kingdom
London, England, United Kingdom
Manchester, England, United Kingdom
Rotherham, England, United Kingdom
Westcliff On Sea, England, United Kingdom
Wolverhampton, England, United Kingdom
Worcester, England, United Kingdom
York, England, United Kingdom
Cardiff, Wales, United Kingdom
Haywards Heath, , United Kingdom
Margate, , United Kingdom
Newcastle Upon Tyne, , United Kingdom
North Shields, , United Kingdom
Patients applied
Trial Officials
Steve Webb, Prof
Study Chair
Monash University, Study Chair REMAP-CAP Australia
Colin McArthur, Dr
Study Chair
Medical Research Institute of New Zealand, Study Chair REMAP-CAP New Zealand
Marc Bonten, Prof
Study Chair
UMC Utrecht, Study Chair REMAP-CAP Europe
Lennie Derde, MD
Study Chair
UMC Utrecht, Coordinating Investigator REMAP-CAP Europe
John Marshall, Prof
Study Chair
Unity Health Toronto, Study Chair REMAP-CAP Canada
Derek Angus, Prof
Study Chair
University of Pittsburgh Medical Center, Study Chair REMAP-CAP USA
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Similar Trials