Hereditary Risk Factors for Thyroid Cancer

Launched by DANA-FARBER CANCER INSTITUTE · Apr 19, 2016

Keywords

ClinConnect Summary

This clinical trial is looking at hereditary risk factors for thyroid cancer, which means they want to understand how genes and family history might make some people more likely to develop this type of cancer. The researchers are especially interested in children and families where thyroid cancer appears to run in the family. To do this, they will collect information about participants' medical and family histories and gather blood or saliva samples for genetic testing.

If you or your child has ever had thyroid cancer or nodules (small lumps in the thyroid), or if there is a family history of thyroid cancer, you may be eligible to participate. The study is open to both children and adults, and they are seeking families with a strong suspicion that their thyroid cancer may be hereditary. Participants can expect to provide information about their health and family history, and contribute a sample for the genetic study. This research aims to help scientists better understand the causes of thyroid cancer, which could improve prevention and treatment options in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Individual pediatric patient with current or previous known or suspected thyroid cancer or nodule(s).
• • Individual adult patient with current or previous known or suspected thyroid cancer or nodule(s) if they come from a family with a high suspicion of hereditary cancer (as below).
• * Individuals from families with a high suspicion of hereditary thyroid cancer:
• • Families with a current or previous diagnosis of a thyroid cancer/nodule occurring in childhood (\<18 years old).
• * Families with a high suspicion of hereditary thyroid cancer/nodules other than above to include:
• • Families with thyroid cancer in multiple individuals
• • Families with thyroid cancer and a known genetic syndrome
• • Families with thyroid cancer and a suspected genetic syndrome (e.g. multiple childhood cancers in the family, multiple primary cancers, multiple endocrinopathies, etc.)
• Exclusion Criteria:
• • Individuals who are unable to give informed consent.
• • Individuals who are unable to complete study materials.