Carotid Atherosclerosis : Innovative Imaging Biomarkers. Study Case-control

Launched by HOSPICES CIVILS DE LYON · Apr 19, 2016

Keywords

ClinConnect Summary

This clinical trial is studying a condition called carotid stenosis, which involves narrowing of the carotid arteries that can lead to strokes. The goal of the trial is to explore new imaging techniques to better understand the characteristics of the plaque in these arteries. By combining various methods, researchers hope to predict which patients are at higher risk for having a stroke or a mini-stroke (known as a transient ischemic attack, or TIA) due to unstable plaques.

To participate in the study, you need to be between the ages of 65 and 74 and have at least 50% narrowing of your carotid artery. If you have had a stroke on the same side as the narrowing, you would be in the "case" group, while those without a recent stroke would be considered "controls." Over two years, the study will involve around 150 participants, and you can expect to undergo a series of imaging tests to evaluate your condition. It's important to know that certain health conditions and requirements (like being able to understand French and signing consent) will determine if you can join the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Carotid stenosis ≥ 50% NASCET
• • Case: ipsilateral carotid stenosis stroke, certified by MRI or CT in the preceding month, with no others causes of stroke
• • Control: no clinical sign or MRI hint for a recent stroke
• • Signed informed consent form
• • Patient affiliated to a social security system or equivalent
• Exclusion Criteria:
• • Modified Rankin scale \> 3
• • Homolateral stroke or TIA \> 1 month
• • Medical history of homolateral carotid surgery, cervical radiation, carotid occlusive, homolateral intracranial stenosis, risk of developing arterial thromboembolic events
• • Renal failure (creatinine clearance \< 50 ml/min)
• • Contraindication to ultrasound (sonovue)
• • Contraindication to MRI and its contrast media (Gadolinium)
• • Inability to sign informed consent
• • Inability to undergo any of the technics (claustrophobia...)
• • Serious co-morbid disease, dementia
• • Neurological disease with no carotid disease
• • Risk of pregnancy or pregnancy or breastfeeding
• • Adult under reinforced guardianship or legal guardian
• • Patient not understanding French