Evaluating the Neurobiological Basis of Traumatic Dissociation in Women with Histories of Abuse and Neglect

Launched by MCLEAN HOSPITAL · Apr 29, 2016

Keywords

ClinConnect Summary

Dissociative symptoms commonly are associated with exposure to traumatic stress. Preliminary evidence from functional magnetic resonance imaging-based analysis (fMRI) of neural activation during dissociative symptom provocation in patients with PTSD or DID has implicated certain key structures involved in the generation of dissociative symptoms. Given the presumed region-to-region neural interplay implicit within this model, the investigators believe the use of intrinsic functional connectivity MRI (fcMRI) represents a valuable next line of investigation into the neurobiology of traumatic d...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Female
• • Clinical diagnosis of PTSD or DID and history of childhood abuse, or healthy controls
• • Age between 18 and 89
• • Legal and mental competency of the patient
• Exclusion Criteria:
• • Male
• • Under 18 or over 89
• • Legal or mental incompetence
• • Delirium secondary to medical illness
• • PTSD or DID due to general medical or neurological illness
• • History of neurological conditions that may cause significant psychiatric symptomatology (e.g., dementia)
• • Any contraindication to MR scans, including claustrophobia, pregnancy, metal implants, etc.
• • Current alcohol or substance dependence or abuse (within the last month)
• • A history of schizophrenia or other psychotic disorder
• • History of head injury or loss of consciousness for longer than 5 min (including concussion)