A Gene Hunting Study for Familial Papillary Thyroid Cancer

Launched by OHIO STATE UNIVERSITY COMPREHENSIVE CANCER CENTER · May 17, 2016

Keywords

ClinConnect Summary

This clinical trial is focused on understanding the genetic factors that may increase the risk of developing familial papillary thyroid cancer (PTC), a type of thyroid cancer that tends to run in families. Researchers are looking to find specific genes that could explain why some people in a family develop this cancer while others do not. The study is currently recruiting participants, including anyone aged 65 to 74, regardless of gender.

To qualify for the trial, participants must have been diagnosed with papillary thyroid cancer and have a family history of the disease, specifically in three or more living relatives. Both affected family members (those with cancer) and unaffected ones (those without cancer) are invited to join, especially if they come from families with multiple cases of PTC. Participants can expect to provide genetic samples and may help researchers gather important information about their family history. This study could lead to a better understanding of the disease and potentially improve cancer risk assessments for families affected by this condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with a diagnosis of PTC and a family history of PTC in 3 or more living relatives
• • Affected and unaffected family members of the proband\*
• • For familial cases (families with 4 or more cases of PTC), participation will be offered to all living family members with PTC or benign thyroid disease as well as selected unaffected first and second degree relatives. Participation may also be offered to spouses when needed for analyzing parent/offspring samples.
• Exclusion Criteria:
• • Known germline predisposition (ex: pathogenic PTEN variant)
• • Non-English speaking