Increasing Mitochondrial Function on Skeletal Muscle Performance in Older Men

Launched by ROYAL DEVON AND EXETER NHS FOUNDATION TRUST · Jun 6, 2016

Keywords

ClinConnect Summary

A defining feature of ageing is loss of muscle mass ('sarcopenia') and associated functional weakness ('dynapenia'). A common characteristic of dynapenia is lowered mitochondrial content and metabolic function, causing reduced aerobic capacity, increased sensations of effort and impaired lipid oxidation (with resultant glucose intolerance). Exercise training improves mitochondrial and muscle function in ageing populations, however such adaptations remain below that of young counterparts, suggesting alternative approaches are required. Pre-clinical studies show that dietary supplementation w...

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Male
• • Age between 65-75 years
• • Body mass index between 19-29
• • No active cardiovascular or metabolic disease
• • No active respiratory disease
• • No current musculoskeletal injuries
• • A sedentary lifestyle (i.e. does not engage in strenuous, planned physical activity)
• • The ability to give informed consent
• Exclusion Criteria:
• • Currently taking a statin drug or NSAIDs
• • Have a current peptic ulcer
• • Have any renal impairment
• • Have a known hypersensitivity to Acipimox