HRIM vs Mucosal Impedance in GERD Participants

Launched by MAYO CLINIC · Jun 21, 2016

Keywords

ClinConnect Summary

Patients referred to the Mayo Clinic Rochester for a clinically indicated high resolution impedance manometry (HRIM), 24 hour impedance pH (MII-pH) study, and esophagogastroduodenoscopy (EGD) will be recruited. Gastroesophageal reflux will be defined as a total 24 hour esophageal acid exposure time ≥5% regardless of concomitant Proton Pump inhibitor (PPI) use. A negative 24 hour MII-pH study will be defined as an acid exposure time ≤2% off PPI therapy or ≤1% if on PPI therapy.

Gender

ALL

Eligibility criteria

• • Patients being seen at Mayo clinic Rochester having a clinically indicated endoscopy, a high resolution impedance manometry and a 24 hour pH impedance study.
• Inclusion criteria:
• • Adults ages 18-90
• • Patients scheduled for or have completed a HRIM ( within 5 days)
• • Patients scheduled for or recently have completed a MII-pH studies ( within 5 days)
• • Patients scheduled for EGD
• Exclusion criteria:
• • Technically limited esophageal HRIM or MII-pH study
• • Patients with HRIM and MII-pH studies not performed within 5 days of each other
• • Patients with EGD not performed within 30 days of HRIM and MII-pH studies
• • Medical conditions such as severe heart or lung disease that preclude safe performance of endoscopy
• • Inability to read due to: Blindness, cognitive dysfunction, or English language illiteracy