Non-Celiac Wheat Sensitivity: Permanent or Transient Condition?

Launched by UNIVERSITY OF PALERMO · Jun 30, 2016

Keywords

ClinConnect Summary

This clinical trial is studying a condition called Non-Celiac Wheat Sensitivity (NCWS), which causes symptoms similar to gluten intolerance but is different from celiac disease and wheat allergy. Unlike celiac disease, where people must avoid gluten for life, it’s not clear if people with NCWS need to avoid wheat permanently or if their sensitivity might go away over time. This study aims to find out how many patients still need to avoid wheat and how many continue to have symptoms when wheat is reintroduced into their diet.

People who might be eligible for this study are those who were previously diagnosed with NCWS using a special test called a double-blind placebo-controlled wheat challenge, which helps confirm the sensitivity by carefully reintroducing wheat without the patient knowing when they are getting it. Participants can expect to be monitored to see if they are still avoiding wheat and whether they still experience symptoms related to wheat intake. This study is important because it could help doctors better understand how to manage NCWS and whether a strict wheat-free diet is always necessary.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients previously diagnosed with NCWS by DBPC challenge.
• Exclusion Criteria:
• • The 22 patients, included in the previous study, who tested positives for anti-endomysial antibodies (EmA) in the culture medium of the duodenal biopsies, even if the villi/crypts ratio in the duodenal mucosa was normal, were excluded from the present study.