The Effects of Bariatric Surgeries on Glucose Metabolism

Launched by THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO · Jul 5, 2016

Keywords

ClinConnect Summary

This clinical trial is investigating how two types of weight-loss surgeries, gastric bypass and sleeve gastrectomy, affect the way our bodies handle sugar after we eat. Researchers want to understand the changes in hormone and nerve signals that happen after these surgeries, especially focusing on patients who experience low blood sugar (hypoglycemia) after gastric bypass surgery.

If you're between the ages of 65 and 74, have had gastric bypass surgery and have had low blood sugar levels below 50 mg/dl, or if you’re a healthy person with no diabetes history, you may be eligible to participate. Participants will visit the Cedars-Sinai Medical Center for the study, where they will undergo tests and evaluations to help researchers gather important information. It’s important to note that individuals with certain health conditions, like active heart or kidney disease, or those who are pregnant, cannot participate. Overall, this study aims to improve understanding of how these surgeries affect blood sugar levels, which could lead to better care for patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Hypoglycemic RYGB patients with documented blood glucose level \<50 mg/dl
• • Asymptomatic individuals with bariatric surgery
• • Healthy non-surgical patients with no personal history of diabetes
• • Subjects must physically be able to come to our clinical research center Cedars-Sinai Medical Center
• Exclusion Criteria:
• • Active heart, lung, liver, gastrointestinal or kidney disease; unable to give informed consent; pregnancy; uncontrolled high blood pressure or high cholesterol; significant anemia (hemoglobin \<11g/dL); prisoners or institutionalized individuals; type 2 diabetes mellitis; development of any serious medical or psychiatric illness during recruitment or studies;
• • RYGB patients will be disqualified if they have gastric outlet obstruction or severe diarrhea.
• • Healthy non-surgical patients with personal history of diabetes
• For administration of atropine, the following exclusions also apply:
• • History of glaucoma
• • Uncontrolled hypertension (any subjects with BP\>140/90 and history of dyslipidemia
• • Taking any medication that might interact with atropine and cannot be stopped will be excluded from the study)
• • Myasthenia gravis
• • Brain pathology
• • Enlarged prostate in men