Genetic Markers of Cardiovascular Disease in Epilepsy

Launched by MAYO CLINIC · Jul 2, 2016

Keywords

ClinConnect Summary

This clinical trial, called "Genetic Markers of Cardiovascular Disease in Epilepsy," is looking into the connections between epilepsy, heart problems, and sudden unexpected death. Epilepsy affects many people, and those with uncontrolled seizures have a higher risk of sudden death, especially if they are under 40. The study aims to find genetic reasons that might explain why some people with epilepsy are at risk of dangerous heart rhythms or sudden death. By identifying these genetic markers, researchers hope to better understand and possibly prevent these serious issues in patients with epilepsy.

To participate in the trial, individuals must be adults aged 18 to 50 who have been diagnosed with epilepsy, seizures, or related heart problems. Additionally, family members of patients who have experienced issues like sudden death or cardiac arrest may also be eligible. Participants will provide blood samples to help researchers identify any genetic factors involved. It's important to know that individuals who cannot give consent, prisoners, or those with specific medical histories, such as traumatic brain injury or brain tumors, cannot take part in this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults ages 18 - 50 with a diagnosis of epilepsy or seizures, or syncope or drowning or cardiac arrest or sudden death or an abnormal ECG suggestive of an arrhythmia
• • Blood-relatives (Aged 18+) of a patient with a history of epilepsy, seizure, cardiac arrest, sudden death, drowning, syncope or arrhythmia
• Exclusion Criteria:
• • Those who are unable to provide written consent.
• • Prisoners (vulnerable population)
• • Seizures secondary to ischemic events
• • Traumatic brain injury resulting in seizures
• • History of cranial surgery
• • History of brain tumor