Microalbuminuria and Allopurinol in Type 1 Diabetes

Launched by PETER ROSSING · Jul 11, 2016

Keywords

ClinConnect Summary

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Albuminuria (≥30 mg/g)
• • Uric Acid ≥ 0,265 mmol/l
• • GFR (glomerular filtration rate) \> 40 ml/min/1.73m2
• Exclusion Criteria:
• • History of gout or xanthinuria or other indications for uric acid lowering therapy such as cancer chemotherapy.
• • Recurrent renal calculi.
• • Current use of azathioprine, 6-mercaptopurine, didanosine, tamoxifen, amoxicillin/ampicillin, or other drugs interacting with allopurinol.
• • Known allergy to xanthine-oxidase inhibitors.
• • Renal transplant.
• • Non-diabetic kidney disease.
• • Home, 24h og clinical BP\>180 or Diastolic BP \>130 mmHg at screening.
• • Cancer treatment within two years before screening.
• • History of hepatitis B or C.
• • History of acquired immune deficiency syndrome or human immunodeficiency virus (HIV) infection.
• • History of alcohol or drug abuse.
• • Breastfeeding or pregnancy or unwillingness to be on contraception throughout the trial.
• • Poor mental function or any other reason to expect patient difficulty in complying with the requirements of the study.
• • Serious pre-existing medical problems other than diabetes, e.g. congestive heart failure, pulmonary insufficiency.