Purastat® vs Standard Therapy for Haemostasis During Endoscopic Submucosal Dissection

Launched by PORTSMOUTH HOSPITALS NHS TRUST · Jul 12, 2016

Keywords

ClinConnect Summary

Endoscopic submucosal dissection (ESD) is an endoscopic technique that involves the use of an endoscopic knife to gently peel off a superficial neoplasia of any size in an en-bloc fashion. It meets the principles of onco-surgery and is associated with excellent outcomes. A difficulty however with the technique is control of bleeding during the procedure. The GI mucosa is a vascular territory and the current method of managing intraprocedural bleeding is electrocautery using either the endoscopic knife itself or the coag grasper. This introduces a thermal injury to the bowel wall and carries...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or Female, aged 18 years or above.
• • An ESD is attempted for clinical indications approved by MDT.
• • Oesophageal or colonic lesion 2-5cm in size
• • Participant is willing and able to give informed consent for participation in the study
• Exclusion Criteria:
• • Known coagulopathy likely to affect risk of bleeding
• • Submucosal tumour
• • Anticoagulation or anti-platelet therapy (apart from single modality aspirin or clopidogrel) which cannot be stopped for clinical reasons
• • Patient preference