Dehydroepiandrosterone (DHEA)Supplementation Pre-IVF(In Vitro Fertilization) Cycles

Launched by SHANGHAI JI AI GENETICS & IVF INSTITUTE · Aug 10, 2016

Keywords

ClinConnect Summary

78 patients were enrolled according to the inclusion criterion. They were randomized into two groups, 40 were in DHEA group and 38 were in control group. The DHEA group received DHEA (Lab Hercules™) 25mg three times a day continuing more than 12 weeks prior to the start of IVF treatment till the day of egg collection and the control group got without any DHEA treatment. All of the IVF women patients were given CC(clomifene citrate)+HMG(human menopausal gonadotropin) protocol for controlled ovarian hyperstimulation. Hormonal profile including E2(estradiol),FSH(follicle-stimulating hormone) ,...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Patients with antral follicle count \<5 or AMH\<1.1ng/ml and a previous poor ovarian reserve (POR)(\</= 3 oocytes with a conventional stimulation protocol using at least 150 IU FSH per day,at least two episodes)
• Exclusion Criteria:
• • Patients with polycystic ovary or polycystic ovary syndrome, patients who had previous chemotherapy, pelvic irradiation or ovarian surgery and patients on hormonal supplementation for any indication at the time of recruitment (e.g. estrogen, testosterone or DHEA).