SOX Versus XELOX for Patients With Peritoneal Metastasis of Colorectal Cancer

Launched by THE FIRST PEOPLE'S HOSPITAL OF CHANGZHOU · Aug 12, 2016

Keywords

ClinConnect Summary

Peritoneal dissemination from colorectal cancer is common, and it has been traditionally regarded as end-stage disease only amenable to palliation by systemic chemotherapy (sCT), or supportive care .Oxaliplatin and oral fluoropyrimidines (capecitabine or S-1) are active agents for colorectal cancer. Recent a phase II trial of combination chemotherapy of oxaliplatin with S-1 (OS) and several phase II trial of combination chemotherapy of oxaliplatin with capecitabine (XELOX) demonstrated good activity and mild toxicity in advanced colorectal cancer. Oxaliplatin and S-1 or capecitabine have di...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Histologically confirmed colorectal adenocarcinoma, initially diagnosed or recurred
• • Peritoneal metastasis of colorectal cancer
• • At least one uni-dimensional measurable lesion by RECIST criteria
• • Age 18 to 80 years old
• • Estimated life expectancy ≥3 months
• • ECOG performance status ≤2
• • Adequate bone marrow function (WBCs ≥ 4,000/µL or absolute neutrophil count ≥ 1,500/µL, platelets ≥ 100,000/µL)
• • Adequate kidney function (creatinine \< 1.5 mg/dL)
• • Adequate liver function (bilirubin \< 2.0 mg/dL, transaminase levels \<2.5 times the upper normal limit)
• • Written informed consent
• Exclusion Criteria:
• • Other tumor type than adenocarcinoma
• • Previous history of chemotherapy (exception : neoadjuvant or adjuvant chemotherapy without oxaliplatin)
• • Presence of CNS metastasis, psychosis, or seizure
• • Obvious bowel obstruction
• • Evidence of serious gastrointestinal bleeding
• • Past or concurrent history of neoplasm other than colorectal adenocarcinoma, except for curatively treated non-melanoma skin cancer or in situ carcinoma of the cervix uteri
• • Pregnant or lactating women, women of childbearing potential not employing adequate contraception
• • Other serious illness or medical conditions