Prospective Evaluation of Adjusted Body Weight Dosing of Acyclovir in Obesity

Launched by WEST VIRGINIA UNIVERSITY · Aug 22, 2016

Keywords

ClinConnect Summary

This clinical trial is studying how to adjust the dosage of acyclovir, a medication used to treat certain infections, specifically for patients who are obese. The goal is to see if using a different method to calculate the dose based on body weight improves treatment outcomes for these patients. Participants will be already hospitalized for other reasons and will not need to make extra trips to the hospital. They will have blood drawn a few times over a 12-hour period, which will help the researchers understand how the medication works in their bodies.

To be eligible for this study, participants must be at least 18 years old, receiving intravenous acyclovir as part of their routine care, and meet specific weight criteria (obese patients must weigh more than 190% of their ideal body weight). The study will include 10 obese patients and 10 non-obese patients who are similar in other ways. Overall, participants can expect to contribute a small amount of blood for testing while receiving standard care in the hospital, and the findings may help improve treatment for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥18 years of age
• • Receiving intravenous acyclovir 5 mg/kg (TBW for normal weight patients and ABW40 for obese patients) as part of their routine care
• • Weight \> 190% of ideal body weight (IBW) for "obese" patients or weight 80-120% of IBW for matched control patients.
• Exclusion Criteria:
• • Receipt of acyclovir or a pro-drug of acyclovir (valacyclovir, ganciclovir, valganciclovir, famciclovir) in the prior 24 hours
• • Serum creatinine \>1.5 mg/dL
• • Hypersensitivity to acyclovir
• • Patients requiring ventilator support or vasopressors in the prior 24 hours
• • Receipt of probenecid, mycophenolate, tenofovir, or zidovudine in the prior 7 days
• • Significant anatomical deformities that influence body habitus (i.e. amputation)
• • Prior inclusion in this study