Neurobiologic, Immunologic, and Rheumatologic Markers in Youth With PANS

Launched by STANFORD UNIVERSITY · Aug 30, 2016

Keywords

ClinConnect Summary

This clinical trial is studying Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS), a condition where children suddenly develop symptoms like obsessive-compulsive behavior and eating restrictions, along with other serious issues such as anxiety, irritability, and changes in school performance. Researchers aim to understand the brain and immune system changes in these children to uncover the underlying causes of PANS, which may be linked to infections or inflammation. This study could help develop better treatments in the future by targeting the specific causes of these symptoms.

To participate, children aged 1-18 who have been diagnosed with PANS and live near Stanford University may be eligible. They should have experienced a sudden onset of symptoms, including OCD or food restriction, along with at least two other related issues like frequent urination or emotional outbursts. Healthy children aged 4-18 without any psychiatric diagnoses can also join the study as a comparison group. Participants will undergo various tests to help researchers learn more about PANS. This research is important as it may lead to improved understanding and management of psychiatric disorders in children.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Children with PANS
• • 1. Age 1-18 at onset of PANS
• • 2. Diagnosis of PANS: abrupt onset of OCD or food restriction, and at least two of the following associated symptoms: frequent urination, worsening handwriting/cognition, inattention, anorexia, separation anxiety, oppositionality, irritability/rage outbursts, and emotional lability.
• • 3. Patients must live within 90 miles of Stanford University and have a new onset of PANS illness
• • 4. Patients must have an established pediatrician within 90 miles of Stanford University for 3 years.
• • Healthy Controls
• • 1. Age 4-18
• • 2. No psychiatric diagnosis
• Exclusion Criteria:
• • Any neuropsychiatric illness that may obscure the clear diagnosis of PANS