Heart Attack Research Program- Imaging Study

Launched by NYU LANGONE HEALTH · Sep 13, 2016

Keywords

ClinConnect Summary

The Heart Attack Research Program (HARP) is a study focused on understanding the causes of heart attacks in patients who have experienced a myocardial infarction (MI) but do not have blocked arteries. This study will use imaging tests to see what might be happening inside the heart and will track participants for up to 10 years to monitor for any further heart-related issues. Researchers are looking for individuals aged 21 and older who have symptoms like chest pain or related discomfort, along with certain test results indicating a heart attack.

If you join this study, you will have regular check-ups every six months to assess your health. To be eligible, you should not have significant blockages in your heart's arteries and must be willing to participate fully in the study. It's important to note that some conditions, like a recent heart procedure or certain medical histories, may exclude you from participating. This study aims to improve our understanding of heart attacks and help develop better treatments for patients like you.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Acute ischemic symptoms compatible with diagnosis of MI, such as chest pain or anginal equivalent symptoms at rest or new onset exertional anginal equivalent symptoms
• * Objective evidence of MI (either or both of the following):
• • Elevation of troponin to above the laboratory upper limit of normal
• • ST segment elevation of ≥1mm on 2 contiguous ECG leads
• • Willing to provide informed consent and comply with all aspects of the protocol
• • Age ≥ 21 years
• Exclusion Criteria:
• • Stenosis ≥50% of any major epicardial vessel on invasive angiography, as determined by the angiographer at the time of clinically ordered cardiac catheterization
• • History of known obstructive coronary artery disease at angiography, including history of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG)
• • Recent use of vasospastic agents, such as cocaine, triptans, or ergot alkaloids (≤1 month)
• • Alternate explanation for troponin elevation, such as hypertensive urgency, acute exacerbation of heart failure, chronic elevation due to kidney disease, pulmonary embolism, cardiac trauma
• • Coronary dissection apparent on angiography
• • Excessive coronary tortuosity which, in the angiographer's opinion, increases the risks of OCT
• • eGFR\<45 or contraindication to additional contrast needed for OCT in the opinion of the angiographer or treating physician
• • Contraindication to MRI (including but not limited to ferromagnetic implants)
• • Pregnancy
• • Thrombolytic therapy for STEMI (qualifying event)