Early Antibiotic Discontinuation in FUO

Launched by UNIVERSITY HOSPITAL, BREST · Sep 14, 2016

Keywords

ClinConnect Summary

Infections are responsible for significant morbidity and mortality in haematological patients, in particular during chemotherapy-induced neutropenia. Guidelines recommend immediate initiation of antibiotic therapy, whose optimal duration is unclear. The primary objective of this study is to evaluate early discontinuation of antibiotic treatment for Fever of Unknown Origin (FUO) in afebrile or febrile neutropenic patients. The secondary objective is to describe the epidemiology of febrile neutropenia (FN) in investigator centre.

Every episode of FN was prospectively identified. In the first...

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Eligibility criteria

• Inclusion Criteria:
• • age ≥ 18 years;
• • presence of a malignant haematological disease combined with chemotherapy-induced neutropenia (polymorphonuclear neutrophil (PMN) count ≤ 500/mm3)
• • fever defined by tympanic temperature of ≥38°C for ≥1 hour or a single temperature of ≥38.3°C
• Exclusion Criteria:
• • Patients without curative care
• • chronic neutropenia (PMN≤ 500/mm3 for 3 months or more)