A Case Control Study to Identify the Role of Epigenetic Regulation of Genes Responsible for Energy Metabolism and Mitochondrial Function in the Obesity Paradox in Cardiac Surgery

Launched by UNIVERSITY OF LEICESTER · Sep 15, 2016

Keywords

ClinConnect Summary

This clinical trial is studying how certain genes related to energy use and cell function are affected by obesity in patients undergoing heart surgery. Specifically, it looks at how these genes might behave differently in obese and non-obese patients when they have a procedure called coronary artery bypass grafting, which helps improve blood flow to the heart. The researchers want to understand if the way these genes are regulated could help explain the "obesity paradox," where some obese patients seem to do better after heart surgery than expected.

To participate in this study, patients must be adults with a history of irregular heartbeats (like atrial fibrillation). However, those with certain health issues, such as severe kidney problems, inflammatory diseases, or those who are pregnant, will not be eligible. If you join the trial, you can expect to provide information about your health and undergo tests to help researchers gather data on how obesity affects heart surgery outcomes. This research could help improve care for patients in the future!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with pre-existing paroxysmal, persistent or chronic atrial fibrillation,
• Exclusion Criteria:
• • Patients with pre-existing inflammatory state: sepsis undergoing treatment, acute kidney injury within 5 days, chronic inflammatory disease, congestive heart failure.
• • Emergency or salvage procedure.
• • Ejection fraction \<30 %.
• • Patient in a critical preoperative state (Kidney Disease: Improving Global Outcomes (KDIGO) Stage 3 AKI \[20\] or requiring inotropes, ventilation or intra-aortic balloon pump).
• • Pregnancy.