Cognitive-Behavioral Therapy for Irritability in Children With Autism Spectrum Disorder and Intellectual Disability
Launched by YALE UNIVERSITY · Sep 22, 2016
Trial Information
Current as of July 25, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
Children with ASD share common symptoms in the core domains of social reciprocity, communication, and repetitive behaviors. In addition to the core symptoms, 50 to 70 percent of children with ASD often exhibit disruptive behavior problems including irritability, tantrums, noncompliance, aggression and self-injury.
In this open pilot study expands clinical research on CBT for irritability to children with autism and mild cognitive impairment. CBT consists of individual weekly sessions dedicated to teaching children to recognize situations that may lead to frustration and to build coping ski...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • DSM-5 diagnosis of Autism Spectrum Disorder
- • Presence of disruptive behaviors such as irritability and anger outbursts
- • IQ between 55 and 85
- • ABC Irritability Scale score greater than or equal to 15
- • Un-medicated or on stable medication regimen
- • Able to complete all study assessment and fMRI procedures
- Exclusion Criteria:
- • Medical or psychiatric condition that would require alternative treatment
About Yale University
Yale University, a prestigious Ivy League institution located in New Haven, Connecticut, is renowned for its commitment to advancing medical research and clinical innovation. With a rich history of academic excellence and a robust infrastructure for scientific inquiry, Yale serves as a leading sponsor for clinical trials aimed at improving patient care and developing new therapeutic approaches. The university's multidisciplinary teams of researchers and clinicians collaborate to conduct rigorous and ethical studies, leveraging cutting-edge technologies and methodologies to address critical health challenges. Through its dedication to fostering an environment of inquiry and discovery, Yale University plays a pivotal role in translating research findings into clinical practice, ultimately enhancing health outcomes for diverse populations.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
New Haven, Connecticut, United States
Patients applied
Trial Officials
Denis Sukhodolsky, PhD
Principal Investigator
Associate Professor
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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