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Search / Trial NCT02914951

Cognitive-Behavioral Therapy for Irritability in Children With Autism Spectrum Disorder and Intellectual Disability

Launched by YALE UNIVERSITY · Sep 22, 2016

Trial Information

Current as of July 23, 2025

Enrolling by invitation

Keywords

Autism Irritability Disruptive Behavior Aggression Behavior Therapy Cognitive Behavioral Therapy Intellectual Disability Cognitive Impairment

ClinConnect Summary

Children with ASD share common symptoms in the core domains of social reciprocity, communication, and repetitive behaviors. In addition to the core symptoms, 50 to 70 percent of children with ASD often exhibit disruptive behavior problems including irritability, tantrums, noncompliance, aggression and self-injury.

In this open pilot study expands clinical research on CBT for irritability to children with autism and mild cognitive impairment. CBT consists of individual weekly sessions dedicated to teaching children to recognize situations that may lead to frustration and to build coping ski...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • DSM-5 diagnosis of Autism Spectrum Disorder
  • Presence of disruptive behaviors such as irritability and anger outbursts
  • IQ between 55 and 85
  • ABC Irritability Scale score greater than or equal to 15
  • Un-medicated or on stable medication regimen
  • Able to complete all study assessment and fMRI procedures
  • Exclusion Criteria:
  • Medical or psychiatric condition that would require alternative treatment

About Yale University

Yale University, a prestigious Ivy League institution located in New Haven, Connecticut, is renowned for its commitment to advancing medical research and clinical innovation. With a rich history of academic excellence and a robust infrastructure for scientific inquiry, Yale serves as a leading sponsor for clinical trials aimed at improving patient care and developing new therapeutic approaches. The university's multidisciplinary teams of researchers and clinicians collaborate to conduct rigorous and ethical studies, leveraging cutting-edge technologies and methodologies to address critical health challenges. Through its dedication to fostering an environment of inquiry and discovery, Yale University plays a pivotal role in translating research findings into clinical practice, ultimately enhancing health outcomes for diverse populations.

Locations

New Haven, Connecticut, United States

Patients applied

0 patients applied

Trial Officials

Denis Sukhodolsky, PhD

Principal Investigator

Associate Professor

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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