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Search / Trial NCT02954120

Chronic Periodontitis and Polycystic Ovary Syndrome

Launched by BEZMIALEM VAKIF UNIVERSITY · Nov 1, 2016

Trial Information

Current as of September 24, 2025

Completed

Keywords

8 Hydroxy 2´ Deoxyguanosine Malondialdehyde Total Antioxidant Status Oxidative Stres

ClinConnect Summary

RESULTS:

Salivary 8-OHdG levels in the PCOSCP and CP groups were statistically higher than those in both the PCOSPH and the PH groups (P \< 0.05). There was no statistical difference between the PCOSCP, CP, and PCOSPH groups with regard to salivary MDA and TAS levels (P \> 0.05). Highest serum 8-OHdG and MDA levels and lowest serum TAS levels were seen in the PCOSCP group (P \< 0.05). Serum 8-OHdG and MDA levels in the PCOSPH group were higher than those in both systemically healthy groups (PH and CP) (P \< 0.05). Salivary TAS levels were highest (P \< 0.05) in the PH group. There was no s...

Gender

FEMALE

Eligibility criteria

  • Inclusion Criteria:
  • Newly diagnosed non-obese PCOS patients
  • Never smokers
  • Had no history of systemic disease
  • BMI\<25 kg/m2
  • Participants had ≥20 teeth present.
  • Exclusion Criteria:
  • Pregnancy
  • Lactation
  • Hemoglobin A1c (HbA1c) ≥ 6.5%
  • 2-h oral glucose tolerance test (OGTT-2h) ≥200
  • Cushing syndrome, non-classic congenital adrenal hyperplasia, hyperprolactinemia, thyroid dysfunction, and androgen-secreting tumors
  • Any drug use within the past 6 months
  • Periodontal treatment within the past 6 months

About Bezmialem Vakif University

Bezmialem Vakif University is a prominent academic institution based in Istanbul, Turkey, dedicated to advancing medical research and education. As a clinical trial sponsor, the university leverages its state-of-the-art facilities and a multidisciplinary team of experts to conduct innovative research that aims to improve patient outcomes and enhance therapeutic strategies. Bezmialem Vakif University is committed to adhering to rigorous ethical standards and regulatory guidelines, ensuring the integrity and reliability of its clinical trials while fostering collaboration with global research communities. Through its initiatives, the university seeks to contribute significantly to the field of medicine and public health.

Locations

İstanbul, Fatih, Turkey

Patients applied

0 patients applied

Trial Officials

Nesrin Saruhan, PhD

Principal Investigator

Eskisehir Osmangazi Üniversitesi

Cenk Fatih Çanakcı, Prof

Study Director

Ataturk University

Saime Ozbek Sebin, Dr

Principal Investigator

Ataturk University

Humeyra Canakcı, Dr

Principal Investigator

Buhara Hastanesi

Metin İngeç, Prof

Principal Investigator

Ataturk University

Ufuk Sezer, Phd

Principal Investigator

Özel Klinik

Ebru Saglam, PhD

Principal Investigator

Saglik Bilimleri Universitesi

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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