Multi-Parametric Quantitative MR Imaging in Evaluation of Brain Tumors

Launched by CASE COMPREHENSIVE CANCER CENTER · Nov 3, 2016

Keywords

ClinConnect Summary

This clinical trial is studying a new imaging method called magnetic resonance fingerprinting (MRF) to improve how we diagnose and assess brain tumors. MRF is a specialized MRI technique that allows for quicker scans and provides detailed information about the tumor tissue. Researchers will compare the results from MRF with other imaging tests and clinical data to see how accurate this new method is in evaluating brain tumors.

To participate in this study, individuals should have a diagnosed brain tumor, either newly diagnosed or previously treated, and be able to give informed consent. This means they need to understand the study and agree to take part, or have a legal representative who can provide consent if they have cognitive difficulties. Participants will undergo several scans at different times, specifically at the beginning and then again at 1, 3, and 6 months after. However, certain people cannot join, such as those with specific medical devices that are not MRI-compatible, pregnant women, and minors. If you or a loved one is interested in this trial, it could be a chance to help improve brain tumor diagnosis for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of intra-axial brain tumor at initial diagnosis or patients with known treated brain tumors on follow-up with concern for imaging progression
• • Ability to understand and the willingness to sign a written informed consent document, or, in cases where the patient may have cognitive impairment, consent by a legal authorized representative or power of attorney
• • Patients with brain metastases undergoing partial brain radiation (gamma knife or SRS) with ability to undergo research scan at baseline, 1 month and , 3 months, and 6 months
• Exclusion Criteria:
• • Patients with ferromagnetic or otherwise non-MRI compatible aneurysm clips.
• • The presence of an implanted pacemaker or implanted defibrillator device.
• • Patients with contraindications for MRI due to embedded foreign metallic objects. Bullets, shrapnel, metalwork fragments, or other metallic material adds unnecessary risk to the patient.
• • Pregnancy. Regular clinical practice already excludes pregnant patients from gadolinium contrast.
• • Implanted medical device not described above that is not MRI-compatible.
• • Known history of severe claustrophobia.
• • Prisoners and members of other vulnerable populations will be excluded from this study. The subject selection population will not regularly include prisoners and other vulnerable population members as these populations will not provide any additional unique information to or uniquely benefit from the study. Non-English speaking population will be excluded from the study due to lack of sufficient resources to pay for translator and interpreter services.
• • Minors will be excluded.