: Vascular Function in Health and Disease

Launched by RUSSELL RICHARDSON · Nov 14, 2016

Keywords

ClinConnect Summary

This clinical trial, titled "Vascular Function in Health and Disease," aims to better understand how blood flow changes in the body as we age and how certain health conditions, like Chronic Obstructive Pulmonary Disease (COPD), Pulmonary Artery Hypertension, Heart Failure, and Hypertension, may affect this process. The study will look specifically at how different chemical factors in the body that control blood vessel function are altered in these conditions, which can impact our ability to exercise and stay active. By studying both healthy individuals and those with these health issues, the researchers hope to identify the reasons behind vascular dysfunction and explore potential treatments to improve blood flow and overall health.

If you're considering participating in this study, you may be eligible if you're between 18 and 30 years old and healthy, or 65 years and older without any significant health issues. Patients with mild to moderate COPD, certain types of pulmonary hypertension, heart failure, or chronic high blood pressure may also join. Participants can expect to undergo assessments that will help researchers understand how their blood vessels are functioning. It's important to note that some individuals with severe conditions or specific medical histories may not qualify for the study. Your participation could contribute to valuable insights into improving cardiovascular health for people of all ages.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy Young Volunteers: 18-30 years of age with no diseases or conditions that would affect their participation in the study
• • Healthy Older Controls: volunteers 65 years of age or older with no diseases or conditions that would affect their participation in the study
• • Coronary Angiography subjects: patients undergoing routine coronary angiography
• • Chronic Obstructive Pulmonary Disease subjects: patients diagnosed with mild to moderate COPD
• • Pulmonary Arterial Hypertension subjects: patients with idiopathic or heritable Group 1 pulmonary arterial hypertension
• • Heart Failure subjects: patients with Class I, II or III New York Heart Association symptoms of Heart Failure
• • Hypertension subjects: patients diagnosed with chronic high blood pressure
• Exclusion Criteria:
• • Severe COPD (use of supplemental oxygen, or have a one-second forced expiratory volume of less than 30% predicted)
• • History of myocardial infarction
• • History of percutaneous coronary revascularization
• • History of coronary artery bypass grafting
• • Unstable angina pectoris
• • History of variant angina
• • Ejection fraction \< 50%
• • Significant renal disease (Glomerular Filtration Rate \< 50 mL/min/1.73m2)
• • Subjects whose medical care or safety may be at risk from undergoing a Magnetic Resonance Imaging examination (e.g. pacemaker, metal implants, certain types of heart valves)
• • Subject is pregnant
• • Subject has physical ailments (other than COPD, PAH, HF, or hypertension) that would prevent them from study participation in the judgment of the investigator