Chemoradiation Versus Esophagectomy for Locally Advanced Esophageal Cancer

Launched by THE FIRST AFFILIATED HOSPITAL OF HENAN UNIVERSITY OF SCIENCE AND TECHNOLOGY · Nov 21, 2016

Keywords

ClinConnect Summary

This clinical trial is studying two different treatments for Chinese patients with locally advanced esophageal squamous cell cancer, which is a type of cancer that occurs in the esophagus (the tube that carries food from the mouth to the stomach). The researchers want to find out whether surgery (esophagectomy) or a combination of chemotherapy and radiation (chemoradiation) works better for these patients. The trial is currently recruiting participants aged between 18 and 75 who have a type of esophageal cancer that can still be removed with surgery and who meet specific health criteria.

If you or a loved one are interested in joining the trial, you would need to have esophageal squamous cell cancer that is located in the middle or lower part of the esophagus and is considered resectable, meaning it can be surgically removed. Participants will be randomly assigned to receive either surgery or chemoradiation and will be monitored closely throughout the study. It's important to note that individuals with certain severe health conditions or those whose cancer has spread to other areas may not be eligible to participate. This study aims to find the best treatment approach to improve outcomes for patients facing this challenging diagnosis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Chinese
• • esophageal squamous cell cancer
• • mid or lower esophageal cancer
• • tumor is resectable disease
• • clinical stage: cT1bN+Mo, or cT2-4aN0-2M0
• Exclusion Criteria:
• • who had distant metastasis to solid visceral organs or local invasion into trachea, descending aorta, or recurrent laryngeal nerve.
• • who had a serious premorbid condition or a poor physical status that compromised a thoracotomy.