PRIMER: Development of Daily Online Magnetic Resonance Imaging for Magnetic Resonance Image Guided Radiotherapy

Launched by INSTITUTE OF CANCER RESEARCH, UNITED KINGDOM · Nov 22, 2016

Keywords

ClinConnect Summary

The PRIMER trial is studying a new way to deliver radiation therapy for patients with adenocarcinoma, a type of cancer. Traditionally, doctors use CT scans to find the tumor before and during treatment, but these scans can expose patients to extra radiation and sometimes make it hard to see the tumor compared to normal tissue. The trial is exploring a new machine called an MR Linac, which combines high-quality MRI scans (that don’t expose patients to extra radiation) with a radiotherapy machine. This technology aims to improve the accuracy of targeting tumors, potentially leading to better treatment outcomes and fewer side effects.

To participate in this trial, you need to be at least 18 years old and either a healthy volunteer or a patient with confirmed invasive carcinoma who is planning to receive radiotherapy. All participants will undergo safety screenings for MRI compatibility, and patient volunteers will need to be under the care of a specific cancer hospital. If you join, you'll have MRI scans before and during your standard treatment, helping researchers develop the technology for future clinical use. It's important to note that some medical conditions may prevent you from participating, especially those related to MRI safety. If you’re considering joining the trial, you’ll receive detailed information and support throughout the process.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All volunteers must undergo and satisfy MRI safety screening
• • Non-patient volunteers must have no known (or suspected) significant medical condition and be 18 years of age
• • Patient volunteers must have histologically confirmed invasive carcinoma of the tumour/target sites listed in this protocol and be under the care of a Clinical Oncologist at the Royal Marsden NHS Foundation Trust or The Christie NHS Foundation Trust and patients be planned to receive radiotherapy to target site to be imaged
• • All volunteers must be willing and able to provide informed consent/assent for the study
• • Paediatric patient volunteers between the ages of 3 and 18 years, will have consent provided by his or her legal guardian who is 18 years of age
• • Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1
• Exclusion Criteria:
• Any conditions that would be a contra-indication to MRI including:
• • Failure to satisfy the MRI safety screening
• • Implanted pacemakers and/or pacing wires
• • Cochlear implants
• • Programmable hydrocephalus shunts
• • Implanted neurostimulation systems
• • Implanted drug infusion pumps
• * Ferromagnetic implants And additional conditions that may place volunteers at increased risk from MRI procedures including:
• • Known susceptibility to seizures or migraines
• • Fever, reduced thermal regulatory capabilities or increased sensitivity to raised body temperature (for example pregnant women)