Bayraktutan Dunhill Medical Trust EPC Study

Launched by UNIVERSITY OF NOTTINGHAM · Nov 29, 2016

Keywords

ClinConnect Summary

Ischaemic stroke develops through an interference with blood supply to the brain and continues to be one of the leading causes of morbidity and mortality in the World. Global medical statistics reveal that \~75% of all stroke patients are older than 65 years and that the stroke occurrence more than doubles every 10 years after the age of 55 in both men and women.

Although various mechanisms may alter the structure and function of the adult brain during the aging process, endothelial dysfunction is regarded as the main pathology that renders cerebral vessels susceptible to atherosclerosis a...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Participants with Stroke:
• • Patients with anterior circulation IS and aged 65 years or older. Independence prior to stroke (mRS\<3). Ability to give informed consent (directly or via consultee).
• • Age Matched Controls (Healthy Volunteers) Individuals aged 65 years or above. No previous history of stroke. Ability to give consent to take part in the study.
• • Young Healthy Volunteers Individuals aged between 18 to 64 years of age. No previous history of stroke. Ability to give consent to take part in the study.
• Exclusion Criteria:
• * Participants with Stroke:
• • Patients with posterior circulation IS and aged below 65 years of age. Patients with recent recurrent IS. Patients with transient ischaemic attack or IS within the last 3 months. Patients with primary intracerebral haemorrhage.
• • Age Matched Controls (Healthy Volunteers) Individuals aged below 65 years of age. Previous history of stroke.
• * Young Healthy Volunteers (18-64):
• • Individuals aged below 18 years or are 65 years of age or above. Previous history of stroke.