Clinical Transcriptomics in Systemic Vasculitis (CUTIS)

Launched by PETER MERKEL · Dec 22, 2016

Keywords

ClinConnect Summary

The CUTIS trial is a research study aimed at understanding certain skin conditions caused by a group of diseases known as vasculitis. Vasculitis occurs when blood vessels become inflamed, and this study specifically looks at skin lesions in patients with different types of this condition, such as Cryoglobulinemic Vasculitis and Eosinophilic Granulomatosis With Polyangiitis. By examining the tissue and genetic material from these skin lesions, researchers hope to learn more about how these diseases work, which could lead to better treatments in the future.

To be eligible for the study, participants need to be 18 years or older and have a specific type of skin lesion that doctors believe is linked to active vasculitis. They should also have a suspected or confirmed diagnosis of one of the listed types of vasculitis. Participants will need to agree to undergo a skin biopsy, which is a procedure where a small sample of skin is taken for analysis. Those who are pregnant, have certain health issues, or cannot provide consent may not be able to participate. Overall, this trial is a chance for individuals with these conditions to contribute to important medical research that could improve understanding and treatment of vasculitis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Have a cutaneous lesion (purpuric macules, palpable purpura, retiform purpura, nodules, ulcers, or urticarial) believed to be related to active vasculitis
• * Have a suspected or confirmed diagnosis of:
• • Cryoglobulinemic vasculitis (CV)
• • Drug-induced vasculitis
• • Eosinophilic granulomatosis with polyangiitis (EGPA)
• • IgA vasculitis
• • Isolated cutaneous vasculitis
• • Granulomatosis with polyangiitis (GPA)
• • Microscopic polyangiitis (MPA)
• • Polyarteritis nodosa (PAN)
• • Urticarial vasculitis
• • Be willing and able to provide written informed consent (or assent for those under
• Exclusion Criteria:
• • You are less than five years old
• • Considered not to be a candidate for a biopsy or have a higher risk of developing an infection, bleeding, etc., from the biopsy, or a doctor believes that the risks for you participating in this study do not outweigh the potential benefit of learning information from your biopsy
• • You have a neutrophil count (type of white blood cell) less than 1500/mm3, platelet count less than 50,000/mm3, or a hemoglobin less than 7 g/dL
• • You have an uncontrolled disease that could prevent you from completing the study procedures
• • You have an active infection at or near the potential biopsy site, have poor circulation, or have bony prominence or other structure that would increase your risk of complications if you participated in this study
• • You are pregnant or nursing
• • You are not able to provide informed consent