Sodium Deposition in Soft Tissues of Patients with Kidney Disease

Launched by CHRIS MCINTYRE · Dec 22, 2016

Keywords

ClinConnect Summary

This clinical trial is studying how sodium, a common element in our diet, is deposited in the skin, muscles, and bones of patients with kidney disease. When kidneys are not working well, excess sodium can build up in the body, leading to inflammation and various health issues. The researchers will use a special imaging technique called sodium MRI to look at how sodium is stored in different groups of people, including those on dialysis, patients with chronic kidney disease, and healthy individuals. They want to understand how this sodium buildup relates to symptoms and other health markers.

To participate in this study, you must be at least 6 years old and fit into one of several categories, such as being on dialysis for over three months, having chronic kidney disease without needing dialysis, or having heart failure. Healthy individuals without these conditions can also join as controls. If you qualify, you can expect to undergo imaging tests and possibly answer questions about your symptoms and health. It’s important to note that pregnant women, those who can’t understand the study details, or individuals who can’t undergo MRI scans are not eligible to participate. This trial aims to improve understanding of kidney disease and its complications, which could lead to better treatments in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age greater than or equal to 6 years
• • For patients on maintenance hemodialysis or peritoneal dialysis: more than 3 months duration of therapy
• • For patients with CKD stage 1-5: CKD stage 1-5 and no indications to start dialysis
• • For heart failure patients: with or without renal dysfunction
• • For healthy controls: lack of kidney disease, heart failure, liver cirrhosis, and peripheral edema
• For subsequent visits (must meet 1 of the below indicators):
• • Change in dialysis prescription
• • Change in renal replacement therapy modality
• • Change in medication
• • Parathyroidectomy
• • Intervention added to or removed from dialysis (i.e. such as but not limited exercise, cooling, and ischemic preconditioning)
• Exclusion Criteria:
• • Pregnant, breastfeeding or intending pregnancy
• • Unable to give consent or understand written information
• • Contraindication to MRI study