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Search / Trial NCT03007121

Intrathecal Morphine Analgesia vs. Continuous Epidural Analgesia vs. Systemic Analgesia in Colorectal Surgery.

Launched by CHARLES UNIVERSITY, CZECH REPUBLIC · Dec 30, 2016

Trial Information

Current as of August 11, 2025

Completed

Keywords

ClinConnect Summary

Introduction

Colorectal surgery is a frequent operation with expected strong post-operative pain. Thoracic epidural analgesia is a preferred method by many authors, but it is not without risks. As patients in our hospital usually stay at a surgical ICU for 24 hours only and epidural infusion of opioids is prohibited at standard wards according to our hospital standards, it seems to be too demanding method. Systemic analgesia with strong opioids is usually an alternative, but high doses of opioids are known to cause side effects. The last possibility is a single-shot intrathecal injection o...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Patients with elective colorectal surgery (left or right hemicolectomy, subtotal colectomy, resection of sigmoid, rectal or cecum)
  • Exclusion Criteria:
  • Known allergy to any of drugs used, coagulopathy, sepsis, cognitive dysfunction and/or inability to understand instruction.
  • Pregnancy (is assessed as a part of pre-operative examination).
  • Abuse of drugs or morphine therapy before surgery.
  • Idiopathic bowel disease.

About Charles University, Czech Republic

Charles University, located in the Czech Republic, is a prestigious institution renowned for its commitment to advancing medical research and education. As a clinical trial sponsor, the university leverages its extensive academic expertise and state-of-the-art facilities to conduct innovative research that aims to improve patient outcomes and contribute to the global medical community. With a focus on ethical standards and rigorous scientific methodologies, Charles University collaborates with various stakeholders to explore new therapies and enhance healthcare practices, fostering a culture of excellence in clinical research.

Locations

Praha, , Czechia

Patients applied

0 patients applied

Trial Officials

Jiri Malek, M.D.

Principal Investigator

3rd Medical Faculty, Charles University and University Hiospital Kralovske Vinohrady

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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