Prophylactic Oral Antibiotics on Sinonasal Outcomes Following Endoscopic Transsphenoidal Surgery for Pituitary Lesions

Launched by ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER, PHOENIX · Jan 5, 2017

Keywords

ClinConnect Summary

This clinical trial is investigating whether taking oral antibiotics after a specific type of surgery for pituitary tumors can help improve nasal and sinus symptoms, reduce the chances of developing sinus infections, and promote healing in the nasal passages. The surgery being studied is called endoscopic transsphenoidal surgery, which is a minimally invasive procedure used to remove pituitary adenomas (tumors in the pituitary gland).

To participate in this study, you need to be an adult between 18 and 85 years old, undergoing surgery for certain types of pituitary tumors, and able to understand some specific questionnaires about your nasal health. Unfortunately, some individuals may not qualify, such as those with a history of severe allergic reactions to antibiotics, certain liver or kidney issues, or other health conditions that could complicate study participation. If you join, you can expect to receive antibiotics after your surgery and be monitored for any changes in your nasal and sinus symptoms. This research aims to improve recovery and outcomes for patients like you after surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patient undergoing endoscopic surgery for resection of pituitary tumors for nonfunctioning adenoma, acromegaly, or prolactinoma
• • Adults \>18 and \<85 years of age
• • English speaking and able to understand the ASK Nasal-12 and SNOT-22 scales
• • Free of any physical, mental, or medical condition which, in the opinion of the investigator, makes study participation inadvisable
• Exclusion Criteria:
• • Anaphylaxis/intolerance to the study drugs
• • Cirrhosis, hepatitis
• • Any solid organ transplant or bone marrow transplant. And any patient felt to be immunocompromised by the investigators
• • Renal failure on dialysis
• • Any subject who is unwilling or unable to sign informed consent for the study
• • Pregnancy
• • Incarcerated patients
• • Cushing's disease
• • Rathke's Cleft cyst or pituitary cyst
• • History of chronic sinusitis
• • Anticipated use of nasal splints
• • Anticipated use of nasal septal flap
• • Active sinusitis
• • Nasal polyps
• • Previous sinus surgery
• • Concurrent antibiotics for another indication (i.e., urinary tract infection)
• • Immunodeficiency