Coronary Artery Plaque Burden and Morphology in Type 2 Diabetes Mellitus.

Launched by SVENDBORG HOSPITAL · Jan 8, 2017

Keywords

ClinConnect Summary

Coronary artery disease (CAD) is the leading cause of death and morbidity in type 2 diabetes mellitus (T2DM) and diabetics holds the same risk for death or myocardial infarction (MI) as patients with a prior (MI) without diabetes. In addition to macrovascular complications, and traditional cardiac risk factors, T2DM is burdened by microvascular dysfunction affecting several organs. The dynamics between microvascular dysfunction, known cardiac risk factors and coronary atherosclerosis in diabetic disease is not well characterized.

In the present study, a primary cohort of 300 type 2 diabeti...

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Eligibility criteria

• Inclusion Criteria:
• • Age \> 18 years
• • Type 1 or 2 diabetes mellitus
• • Ability to provide informed conscent
• Exclusion Criteria:
• • History of CAD
• • Symtoms of CAD (angina)
• • Any tachyarrhythmias making CCTA impossible
• • Glumerular filtration rate (GFR)\< 45 ml/min
• • Allergy to iodine contrast
• • Critical illness with life expectancy less than 1 year
• • Documented heart failure