MTNR1B SNP*Food Timing Interaction on Glucose Control
Launched by UNIVERSIDAD DE MURCIA · Jan 26, 2017
Trial Information
Current as of August 02, 2025
Completed
Keywords
ClinConnect Summary
Late-night dinner eating is associated with increased risk for type-2-diabetes. The underlying mechanism is unclear. One explanatory hypothesis is that the concurrence of elevated circulating melatonin and high glucose concentrations (characterizing late-eating) leads to impaired glucose-tolerance. However, to date, no study has tested the influence of physiological melatonin concentrations on glucose tolerance. The discovery of melatonin receptor MTNR1B as a diabetes risk gene provides evidence for a role of physiological levels of melatonin in glucose control.
The aim of the current stud...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Body Mass Index: \> 18.5 o \< 40 kg/m2
- • Age: between 18 and 65 year of age
- • European ancestry
- • Day workers
- Exclusion Criteria:
- • Receiving treatment with thermogenic, lipogenic, or drugs
- • Diabetes mellitus, chronic renal failure, hepatic diseases, or cancer diagnosis
- • Bulimia diagnosis, prone to binge eating
- • Undergoing treatment with Type 2 diabetes mellitus (high blood sugar) medications such as Metformin or other non-Metformin oral anti-diabetic drugs such as sulfonylureas, meglitinides, or glitazones
- • Undergoing treatment with Corticosteroids/steroids, Growth hormone, Anticoagulant medicines, or blood thinners, Beta blockers for hypertension, Medications for sleep, Fluvoxamine, Opioids or Amphetamines, Tranquilizers, nonsteroidal anti-inflammatory drugs.
- • Pregnant
About Universidad De Murcia
The Universidad de Murcia, a leading academic institution in Spain, is dedicated to advancing medical research and innovation through its clinical trial initiatives. With a strong emphasis on interdisciplinary collaboration and patient-centered approaches, the university conducts rigorous clinical studies aimed at improving health outcomes and contributing to the scientific community. Its skilled team of researchers and healthcare professionals are committed to adhering to the highest ethical standards and regulatory guidelines, ensuring that each trial not only furthers medical knowledge but also prioritizes participant safety and well-being. Through its clinical trials, the Universidad de Murcia strives to translate research findings into practical applications that enhance healthcare practices and policies.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Murcia, , Spain
Patients applied
Trial Officials
Purificación Gomez Abellan, PHD
Study Chair
Universidad de Murcia
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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