Overnight Trials with Heat Stress in Autonomic Failure Patients with Supine Hypertension
Launched by VANDERBILT UNIVERSITY MEDICAL CENTER · Feb 1, 2017
Trial Information
Current as of July 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is looking at how applying heat to the abdomen of patients with certain conditions can help manage high blood pressure while lying down, a problem known as supine hypertension. People with autonomic failure, which can occur in diseases like Parkinson's or Multiple System Atrophy, often experience low blood pressure when they stand up, but some also have high blood pressure when they are lying flat. The study aims to see if local heat during the night can reduce this high blood pressure.
To participate in this study, individuals must be between 18 and 80 years old and diagnosed with primary autonomic failure and supine hypertension, meaning their blood pressure is 150 mmHg or higher while lying down. Participants will need to be able to give consent and should not have serious heart, kidney, or liver issues, or be pregnant. Those who join the study will likely spend time in a controlled environment where they will receive the heat treatment at night, and this could help researchers understand better how to address this challenging condition.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Male and female patients, between 18-80 yrs., with primary autonomic failure (Parkinson Disease, Multiple System Atrophy, and Pure Autonomic Failure) and supine hypertension. Supine hypertension will be defined as SBP≥150 mmHg.
- • Patients able and willing to provide informed consent.
- Exclusion Criteria:
- • Pregnancy
- • Significant cardiac, renal or hepatic illness, or with contraindications to administration of pressor agents or with other factors, which in the investigator's opinion would prevent the subject from completing the protocol including clinically significant abnormalities in clinical, mental or laboratory testing.
About Vanderbilt University Medical Center
Vanderbilt University Medical Center (VUMC) is a leading academic medical center located in Nashville, Tennessee, renowned for its commitment to advancing healthcare through innovative research and clinical excellence. As a prominent sponsor of clinical trials, VUMC integrates cutting-edge scientific inquiry with patient-centered care, supporting a diverse array of studies aimed at enhancing medical knowledge and improving treatment outcomes. With a robust infrastructure and a multidisciplinary team of experts, VUMC fosters collaboration across various fields, ensuring the highest standards of safety and ethical considerations in its research endeavors. Through its dedication to medical discovery and education, VUMC plays a pivotal role in shaping the future of medicine.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Nashville, Tennessee, United States
Patients applied
Trial Officials
Italo Biaggioni, MD
Principal Investigator
Vanderbilt University Medical Center
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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