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Search / Trial NCT03042988

Overnight Trials with Heat Stress in Autonomic Failure Patients with Supine Hypertension

Launched by VANDERBILT UNIVERSITY MEDICAL CENTER · Feb 1, 2017

Trial Information

Current as of July 26, 2025

Recruiting

Keywords

Supine Hypertension Autonomic Failure Heat Stress Orthostatic Hypotension

ClinConnect Summary

This clinical trial is looking at how applying heat to the abdomen of patients with certain conditions can help manage high blood pressure while lying down, a problem known as supine hypertension. People with autonomic failure, which can occur in diseases like Parkinson's or Multiple System Atrophy, often experience low blood pressure when they stand up, but some also have high blood pressure when they are lying flat. The study aims to see if local heat during the night can reduce this high blood pressure.

To participate in this study, individuals must be between 18 and 80 years old and diagnosed with primary autonomic failure and supine hypertension, meaning their blood pressure is 150 mmHg or higher while lying down. Participants will need to be able to give consent and should not have serious heart, kidney, or liver issues, or be pregnant. Those who join the study will likely spend time in a controlled environment where they will receive the heat treatment at night, and this could help researchers understand better how to address this challenging condition.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Male and female patients, between 18-80 yrs., with primary autonomic failure (Parkinson Disease, Multiple System Atrophy, and Pure Autonomic Failure) and supine hypertension. Supine hypertension will be defined as SBP≥150 mmHg.
  • Patients able and willing to provide informed consent.
  • Exclusion Criteria:
  • Pregnancy
  • Significant cardiac, renal or hepatic illness, or with contraindications to administration of pressor agents or with other factors, which in the investigator's opinion would prevent the subject from completing the protocol including clinically significant abnormalities in clinical, mental or laboratory testing.

About Vanderbilt University Medical Center

Vanderbilt University Medical Center (VUMC) is a leading academic medical center located in Nashville, Tennessee, renowned for its commitment to advancing healthcare through innovative research and clinical excellence. As a prominent sponsor of clinical trials, VUMC integrates cutting-edge scientific inquiry with patient-centered care, supporting a diverse array of studies aimed at enhancing medical knowledge and improving treatment outcomes. With a robust infrastructure and a multidisciplinary team of experts, VUMC fosters collaboration across various fields, ensuring the highest standards of safety and ethical considerations in its research endeavors. Through its dedication to medical discovery and education, VUMC plays a pivotal role in shaping the future of medicine.

Locations

Nashville, Tennessee, United States

Patients applied

0 patients applied

Trial Officials

Italo Biaggioni, MD

Principal Investigator

Vanderbilt University Medical Center

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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