Timing of Delivery in Fetal Growth Restriction of Uncomplicated Women

Launched by THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER, HOUSTON · Feb 6, 2017

Keywords

ClinConnect Summary

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Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Singleton pregnancy
• • Gestational age 34 weeks 0 days to 37 weeks 0 days at time of enrollment
• • Dating of pregnancy by last menstrual period consistent with an ultrasound, ultrasound \<21 weeks and 6 days of gestation, or known date of conception in the setting of in vitro fertilization
• • No known major anomalies (anomalies requiring surgery antenatally or in the neonatal period, anomalies not compatible with life as determined by the physician)
• • FGR defined as estimated fetal weight (EFW) \< 10th percentile by Hadlock formula with normal umbilical artery Doppler studies and normal amniotic fluid
• Exclusion Criteria:
• • Known major fetal anomalies
• • Multiple gestation or selective reduction of multiple gestation after 14 weeks
• • Previous stillbirth at term
• * Indications for delivery at \<39 weeks. Common examples include:
• • Placenta previa
• • Placenta accreta
• • Vasa previa
• • History of classical cesarean section or myomectomy
• • Human immunodeficiency virus (HIV)
• • Oligohydramnios (low amniotic fluid, defined as maximum vertical pocket \<2.0cm)
• * High-risk pregnancy as determined by the physician. Common examples include:
• • Pre-gestational diabetes or gestational diabetes on medication
• • Chronic hypertension on medication
• • Maternal cardiac disease
• • Asthma requiring oral steroids during pregnancy
• • Chronic renal disease
• • Antiphospholipid syndrome
• • Hyperthyroidism
• • Prior stillbirth
• • Systemic lupus erythematous
• • Hemoglobinopathies such as sickle cell disease