Familial Investigations of Childhood Cancer Predisposition

Launched by ST. JUDE CHILDREN'S RESEARCH HOSPITAL · Feb 8, 2017

Keywords

ClinConnect Summary

This clinical trial, called "Familial Investigations of Childhood Cancer Predisposition," is studying how certain genetic factors may increase the risk of developing specific types of childhood cancers. Researchers are interested in finding new genes that could lead to cancer, especially in families where multiple members have been diagnosed with cancer at a young age. They will collect health information, blood samples, and sometimes leftover tumor samples from participants to help identify these genetic links.

To be eligible for this study, you or a family member must have a history of cancer diagnosed at a young age, or have been diagnosed with more than one cancer. Close relatives, whether they have cancer or not, are also welcome to participate. It's important to know that this study is separate from clinical genetic testing, and while you may not receive immediate results, the information gathered could help improve cancer diagnosis and care in the future. If you're interested in clinical testing or need immediate answers, it's best to consult a local genetic counselor.

Gender

ALL

Eligibility criteria

• • NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll. If you are interested in clinical testing please consider seeing a local genetic counselor or other genetics professional. If you have already had clinical genetic testing and meet eligibility criteria for this study as shown below, you may enroll regardless of the results of your clinical genetic testing.
• DEFINITION OF FAMILIAR CANCER FOR THIS PROTOCOL:
• In this protocol, the definition of "Familial Cancer" is met if any of the following is present:
• • An individual with a history of cancer diagnosed under 26 years of age who has at least one first, second or third degree relative with a history of cancer diagnosed under 51 years of age; OR
• • An individual who has been diagnosed with more than one cancer, at least one of which was diagnosed under 26 years of age; OR
• • An individual with a clinical or molecular diagnosis of a known cancer predisposition syndrome; OR
• • An individual with a congenital cancer diagnosed before 6 months of age; OR
• • An individual with a rare pediatric cancer or tumor diagnosed before 26 years of age
• • º Excluding human papilloma virus-associated cervical cancer and non-melanoma skin cancer occurring in adults.
• INCLUSION CRITERIA:
• • An individual who meets this protocol's definition of "Familial Cancer," as above.
• • Biologic relatives of an individual meeting this protocol's definition of "Familial Cancer," who are either affected or unaffected by cancer.
• EXCLUSION CRITERIA:
• • An inability or unwillingness of the research participant or his/her legally authorized representative (LAR) to provide written informed consent.
• • The participant has received allogeneic bone marrow transplantation and has NO pre-transplant germline (cancer-unaffected) DNA available AND is unwilling to provide a skin sample.