Glittre ADL-test: Responsiveness to Acute Bronchodilation in Chronic Obstructive Pulmonary Disease (COPD)

Launched by LAVAL UNIVERSITY · Mar 1, 2017

Keywords

ClinConnect Summary

METHODOLOGY: Study design and setting: It will be a randomized double-blind trial during which 34 patients with moderate to severe COPD will complete 2 Glittre ADL-tests 15 minutes following nebulization of a placebo or of ipratropium bromide/salbutamol sulfate combination. Patients receiving bronchodilators before the beginning of the study will be asked to withdraw from their medication 8h in the case of short-acting bronchodilators and/or 72 h in the case of long-acting bronchodilators before visits. Those treated with tiotropium will have a 4-week washout period during which this therap...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosis of moderate to severe COPD based on the GOLD spirometric classification
• • able to provide written informed consent
• • able to follow verbal directions for testing.
• Exclusion Criteria:
• • diagnosed with cardiovascular, neurological or, neuromuscular conditions that could affect ability to perform the tests (e.g. stroke, knee osteoarthritis);
• • currently participating in a structured exercise or pulmonary rehabilitation program or been involved in pulmonary rehabilitation in the past 6 months;
• • experienced a COPD exacerbation in the past 6 weeks
• • receiving a daily dose \> 10mg of oral Prednisone within the past 3 months
• • unable to walk 4 metres without use of a gait aid (e.g. walker, cane)
• • receiving oxygen supply