A Study Comparing Upadacitinib (ABT-494) to Placebo in Participants With Active Psoriatic Arthritis Who Have a History of Inadequate Response to at Least One Biologic Disease Modifying Anti-Rheumatic Drug
Launched by ABBVIE · Apr 4, 2017
Trial Information
Current as of July 21, 2025
Completed
Keywords
ClinConnect Summary
No description provided
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Clinical diagnosis of PsA with symptom onset at least 6 months prior to the Screening Visit and fulfillment of the Classification Criteria for PsA (CASPAR) criteria
- • Participant has active disease at Baseline defined as \>= 3 tender joints (based on 68 joint counts) and \>= 3 swollen joints (based on 66 joint counts) at Screening and Baseline Visits
- • Diagnosis of active plaque psoriasis or documented history of plaque psoriasis
- • Participant has had an inadequate response (lack of efficacy after a minimum 12 week duration of therapy) or intolerance to treatment with at least 1 bDMARD.
- Exclusion Criteria:
- • Prior exposure to any Janus Kinase (JAK) inhibitor (including but not limited to ruxolitinib, tofacitinib, baricitinib, and filgotinib)
- • Current treatment with \> 2 non-biologic DMARDs or use of DMARDs other than Methotrexate (MTX), Sulfasalazine (SSZ), Leflunomide (LEF), apremilast, Hydroxychloroquine (HCQ), bucillamine or iguratimod or use of MTX in combination with LEF at Baseline.
- • History of fibromyalgia, any arthritis with onset prior to age 17 years, or current diagnosis of inflammatory joint disease other than PsA (including, but not limited to rheumatoid arthritis, gout, overlap connective tissue diseases, scleroderma, polymyositis, dermatomyositis, systemic lupus erythematosus). Prior history of reactive arthritis or axial spondyloarthritis including ankylosing spondylitis and non-radiographic axial spondyloarthritis is permitted if documentation of change in diagnosis to PsA or additional diagnosis of PsA is made. Prior history of fibromyalgia is permitted if documentation of change in diagnosis to PsA or documentation that the diagnosis of fibromyalgia was made incorrectly.
About Abbvie
AbbVie is a global biopharmaceutical company dedicated to developing innovative therapies that address complex health challenges. Founded in 2013 as a spin-off from Abbott Laboratories, AbbVie focuses on key therapeutic areas, including immunology, oncology, neuroscience, and virology. The company is committed to advancing scientific research and delivering groundbreaking treatments that enhance patient outcomes and quality of life. With a robust pipeline and a strong emphasis on collaboration, AbbVie strives to transform the future of medicine through its commitment to clinical excellence and patient-centered approaches.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Mobile, Alabama, United States
Mesa, Arizona, United States
Peoria, Arizona, United States
Phoenix, Arizona, United States
Covina, California, United States
El Cajon, California, United States
Fullerton, California, United States
Hemet, California, United States
Huntington Beach, California, United States
La Mesa, California, United States
Stanford, California, United States
Upland, California, United States
Whittier, California, United States
Denver, Colorado, United States
Aventura, Florida, United States
Clearwater, Florida, United States
Daytona Beach, Florida, United States
Miami Lakes, Florida, United States
New Port Richey, Florida, United States
Ormond Beach, Florida, United States
Palm Harbor, Florida, United States
Pensacola, Florida, United States
Saint Petersburg, Florida, United States
Sarasota, Florida, United States
Tamarac, Florida, United States
Tampa, Florida, United States
Tampa, Florida, United States
Tampa, Florida, United States
Zephyrhills, Florida, United States
Marietta, Georgia, United States
Chicago, Illinois, United States
Skokie, Illinois, United States
Vernon Hills, Illinois, United States
Monroe, Louisiana, United States
Wheaton, Maryland, United States
Worcester, Massachusetts, United States
Springfield, Missouri, United States
Omaha, Nebraska, United States
Toms River, New Jersey, United States
Las Cruces, New Mexico, United States
Albany, New York, United States
Potsdam, New York, United States
Charlotte, North Carolina, United States
Wilmington, North Carolina, United States
Minot, North Dakota, United States
Vandalia, Ohio, United States
Oklahoma City, Oklahoma, United States
Duncansville, Pennsylvania, United States
Summerville, South Carolina, United States
Knoxville, Tennessee, United States
Memphis, Tennessee, United States
Austin, Texas, United States
Beaumont, Texas, United States
Corpus Christi, Texas, United States
Dallas, Texas, United States
Houston, Texas, United States
Lufkin, Texas, United States
Mesquite, Texas, United States
Tomball, Texas, United States
Waco, Texas, United States
Seattle, Washington, United States
Ghent, Oost Vlaanderen, Belgium
Genk, , Belgium
Goiânia, Goias, Brazil
Uberlândia, Minas Gerais, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Ribeirao Preto, Sao Paulo, Brazil
Santo André, Sao Paulo, Brazil
São Paulo, Sao Paulo, Brazil
Victoria, British Columbia, Canada
Winnipeg, Manitoba, Canada
Barrie, Ontario, Canada
Sainte Foy, Quebec, Canada
Trois Rivières, Quebec, Canada
Providencia, , Chile
Santiago, , Chile
Santiago, , Chile
Vitacura Santiago, , Chile
Bruntál, , Czechia
Uherské Hradište, , Czechia
Marseille Cedex 08, Bouches Du Rhone, France
Toulouse Cedex 3, Occitanie, France
Paris, , France
Tours, , France
Athens, Attiki, Greece
Athens, , Greece
Budapest, , Hungary
Budapest, , Hungary
Debrecen, , Hungary
Szolnok, , Hungary
Veszprem, , Hungary
Reggio Emilia, Emilia Romagna, Italy
Ancona, Marche, Italy
Catania, , Italy
Milan, , Italy
Nagoya Shi, Aichi, Japan
Fukuoka Shi, Fukuoka, Japan
Kitakyushu Shi, Fukuoka, Japan
Asahikawa Shi, Hokkaido, Japan
Tsu Shi, Mie, Japan
Sendai Shi, Miyagi, Japan
Oita Shi, Oita, Japan
Hirakata Shi, Osaka, Japan
Kawachinagano Shi, Osaka, Japan
Osaka Shi, Osaka, Japan
Osaka Shi, Osaka, Japan
Bunkyo Ku, Tokyo, Japan
Chuo Ku, Tokyo, Japan
Shinjuku Ku, Tokyo, Japan
Nagoya, , Japan
Rotterdam, , Netherlands
Rotterdam, , Netherlands
Hamilton, Waikato, New Zealand
Auckland, , New Zealand
Nelson, , New Zealand
Timaru, , New Zealand
Lisbon, Lisboa, Portugal
Lisbon, Lisboa, Portugal
Vila Nova De Gaia, Porto, Portugal
Lisboa, , Portugal
Viana Do Castelo, , Portugal
Ponce, , Puerto Rico
San Juan, , Puerto Rico
A Coruña, A Coruna, Spain
El Palmar, Murcia, Spain
Cordoba, , Spain
Bath, Bath And North East Somerset, United Kingdom
London, London, City Of, United Kingdom
Luton, , United Kingdom
Mesa, Arizona, United States
Peoria, Arizona, United States
Phoenix, Arizona, United States
Beverly Hills, California, United States
Fullerton, California, United States
Huntington Beach, California, United States
La Mesa, California, United States
Lakewood, Colorado, United States
Aventura, Florida, United States
Daytona Beach, Florida, United States
Miami Lakes, Florida, United States
New Port Richey, Florida, United States
Tamarac, Florida, United States
Tampa, Florida, United States
Tampa, Florida, United States
Decatur, Georgia, United States
Meridian, Idaho, United States
Libertyville, Illinois, United States
Skokie, Illinois, United States
Frederick, Maryland, United States
Wheaton, Maryland, United States
Worcester, Massachusetts, United States
Springfield, Missouri, United States
Las Cruces, New Mexico, United States
Albany, New York, United States
Charlotte, North Carolina, United States
Greenville, North Carolina, United States
Raleigh, North Carolina, United States
Pittsburgh, Pennsylvania, United States
Beaumont, Texas, United States
College Station, Texas, United States
Houston, Texas, United States
Tomball, Texas, United States
Arlington, Virginia, United States
Seattle, Washington, United States
Botany, New South Wales, Australia
Woodville South, South Australia, Australia
Box Hill, Victoria, Australia
Heidelberg West, Victoria, Australia
Genk, Limburg, Belgium
Gent, Oost Vlaanderen, Belgium
Santo André, La Spezia, Brazil
Ribeirão Preto, Sao Paulo, Brazil
Sao Paulo, , Brazil
Winnipeg, Manitoba, Canada
Orillia, Ontario, Canada
Trois Rivières, Quebec, Canada
Providencia, Aisen Del General Carlos Ibanez Del Campo, Chile
Santiago, , Chile
Santiago, , Chile
Prostejov, , Czechia
Uherske Hradiste, , Czechia
Marseille, Bouches Du Rhone, France
Toulouse, Occitanie, France
Le Mans Cedex 9, Sarthe, France
Chambray Les Tours, , France
Creteil, , France
Paris, , France
Athens, Attiki, Greece
Larisa, , Greece
Gyor, Gyor Moson Sopron, Hungary
Veszprém, Veszprem, Hungary
Budapest, , Hungary
Budapest, , Hungary
Debrecen, , Hungary
Szolnok, , Hungary
Napoli, L Aquila, Italy
Rome, Roma, Italy
Rome, Roma, Italy
Ancona, , Italy
Catania, , Italy
Cona, , Italy
Milan, , Italy
Reggio Emilia, , Italy
Nagoya Shi, Aichi, Japan
Nagoya Shi, Aichi, Japan
Kitakyushu Shi, Fukuoka, Japan
Kitakyushu Shi, Fukuoka, Japan
Sendai Shi, Miyagi, Japan
Kawachinagano Shi, Osaka, Japan
Osaka Shi, Osaka, Japan
Suwon, Gyeonggido, Korea, Republic Of
중구, , Korea, Republic Of
Leeuwarden, Zuid Holland, Netherlands
Rotterdam, Zuid Holland, Netherlands
Rotterdam, Zuid Holland, Netherlands
Ubbergen, , Netherlands
Otahuhu, Auckland, New Zealand
Timaru, Canterbury, New Zealand
Hamilton, Waikato, New Zealand
Vila Nova De Gaia, Porto, Portugal
Ponte De Lima, Viana Do Castelo, Portugal
Lisboa, , Portugal
Lisboa, , Portugal
Lisboa, , Portugal
Carolina, , Puerto Rico
Ponce, , Puerto Rico
San Juan, , Puerto Rico
A Coruna, , Spain
Cordoba, , Spain
Granada, , Spain
Madrid, , Spain
Bath, Bath And North East Somerset, United Kingdom
London, London, City Of, United Kingdom
London, London, City Of, United Kingdom
Glasgow, , United Kingdom
Luton, , United Kingdom
Poole, , United Kingdom
중구, Incheon Gwang Yeogsi, Korea, Republic Of
London, , United Kingdom
London, , United Kingdom
Patients applied
Trial Officials
ABBVIE INC.
Study Director
AbbVie
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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